Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 2/20 | 0.52 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 9/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10515957 | 1.00 | HDAC4 (0.54) | HDAC4HDAC8HDAC3HDAC1HDAC7 | |
| SCHEMBL10514668 | 0.89 | PIM1 (0.59) | HDAC4PIM1PIM2HPGDAKR1B1 | |
| SCHEMBL10514663 | 0.89 | PIM1 (0.59) | HDAC4PIM1PIM2HPGDAKR1B1 | |
| SCHEMBL10515962 | 0.87 | HDAC3 (0.54) | HDAC4HDAC8HDAC3HDAC1HDAC7 | |
| SCHEMBL10514534 | 0.85 | IGF1R (0.49) | HDAC4PIM1PIM2HPGDMEN1 | |
| SCHEMBL10514536 | 0.85 | IGF1R (0.49) | HDAC4PIM1PIM2HPGDMEN1 | |
| SCHEMBL1247957 | 0.83 | PIM1 (0.46) | PIM1PIM2PIM3HPGD | |
| SCHEMBL1247959 | 0.83 | PIM1 (0.46) | PIM1PIM2PIM3HPGD | |
| SCHEMBL10513564 | 0.82 | PIM1 (0.42) | HDAC4HDAC8PIM1PIM2PIM3 | |
| SCHEMBL10513557 | 0.82 | PIM1 (0.42) | HDAC4HDAC8PIM1PIM2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299620-A1 | Thiazolidinedione derivatives | BEECHAM GROUP PLC (GB) | 1989-01-18 | — | — | EP | claimed |
| EP-0299620-A1 | Thiazolidinedione derivatives | BEECHAM GROUP PLC (GB) | 1989-01-18 | — | — | EP | disclosed |