Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLH | Q9Y253 | 4/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.44 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10515595 | 0.88 | CYP3A4 (0.54) | POLHALOX5MEN1MAPTKMT2A | |
| SCHEMBL10668666 | 0.84 | POLH (0.59) | POLHALOX5MEN1MAPTKMT2A | |
| SCHEMBL10516813 | 0.84 | POLH (0.59) | POLHALOX5MEN1MAPTKMT2A | |
| SCHEMBL10514913 | 0.84 | POLH (0.59) | POLHALOX5MEN1MAPTKMT2A | |
| SCHEMBL10516409 | 0.82 | ATP1A1 (0.46) | POLHALOX5MEN1MAPTKMT2A | |
| SCHEMBL9270632 | 0.80 | CYP3A4 (0.74) | POLHMEN1MAPTKMT2ACYP3A4 | |
| SCHEMBL10516809 | 0.79 | CYP3A4 (0.53) | POLHMEN1MAPTKMT2ACYP3A4 | |
| SCHEMBL10516343 | 0.79 | CYP3A4 (0.66) | POLHMEN1MAPTKMT2ACYP3A4 | |
| SCHEMBL10665463 | 0.78 | CYP3A4 (0.55) | POLHALOX5MEN1MAPTKMT2A | |
| SCHEMBL10515926 | 0.77 | CYP3A4 (0.54) | POLHALOX5MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0183169-B1 | HALOGEN-HYDROXY FLAVONE | MERCK PATENT GmbH (DE) | 1989-05-10 | — | — | EP | disclosed |
| US-4788215-A | TREATMENT OF HYPERTHYROIDISM | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1988-11-29 | — | — | US | disclosed |
| US-4713465-A | Flavanone intermediates for halogenohydroxyflavones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1987-12-15 | — | — | US | disclosed |
| EP-0183169-A2 | Halogen-hydroxy flavone | MERCK PATENT GmbH (DE) | 1986-06-04 | — | — | EP | disclosed |