Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.41 |
| ▸ | PTGES | O14684 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31174999 | 0.88 | KDM5A (0.46) | KDM5AKDM5BKDM4EALDH1A1LMNA | |
| SCHEMBL30240636 | 0.88 | KDM5A (0.46) | KDM5AKDM5BKDM4EALDH1A1LMNA | |
| SCHEMBL23951030 | 0.88 | KDM5A (0.46) | KDM5AKDM5BKDM4EALDH1A1LMNA | |
| SCHEMBL25187813 | 0.88 | KDM5A (0.46) | KDM5AKDM5BKDM4EALDH1A1LMNA | |
| SCHEMBL6201222 | 0.81 | KDM5A (0.50) | KDM5AKDM5BKDM4EALDH1A1LMNA | |
| SCHEMBL30197952 | 0.81 | KDM5A (0.40) | KDM5AKDM5BKDM4EALDH1A1LMNA | |
| SCHEMBL6198339 | 0.80 | KDM5A (0.48) | KDM5AKDM5BKDM4EALDH1A1LMNA | |
| SCHEMBL5500146 | 0.77 | KDM5A (0.44) | KDM5AKDM5BKDM4EALDH1A1LMNA | |
| SCHEMBL31433701 | 0.77 | KDM5A (0.54) | KDM5AKDM5BKDM4EALDH1A1LMNA | |
| SCHEMBL4647324 | 0.74 | ALDH1A1 (0.51) | KDM5AKDM5BKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0184384-B1 | SUBSTITUTED DIHYDROQUINOLONE CARBOXYLIC ACIDS, ANTI-BACTERIAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1989-08-02 | — | — | EP | disclosed |
| US-4623650-A | BACTERICIDES | PFIZER INC. (US) | 1986-11-18 | — | — | US | disclosed |
| EP-0184384-A1 | Substituted dihydroquinolone carboxylic acids, anti-bacterial compositions containing them | PFIZER INC. (US) | 1986-06-11 | — | — | EP | disclosed |