Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.42 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.42 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.42 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4117558 | 0.77 | ALDH1A1 (0.51) | MAPTLMNAKDM4EPOLBHTT | |
| SCHEMBL1202228 | 0.76 | KDM4E (0.57) | MAPTLMNAKDM4ECYP1A2KMT2A | |
| SCHEMBL14899552 | 0.74 | KDM4E (0.49) | MAPTLMNAKDM4ECYP1A2KMT2A | |
| SCHEMBL30878582 | 0.74 | HTR2C (0.55) | MAPTLMNAKDM4EPOLBACHE | |
| SCHEMBL1011242 | 0.74 | HTR2C (0.55) | MAPTLMNAKDM4EPOLBACHE | |
| SCHEMBL4123425 | 0.73 | TSHR (0.43) | MAPTLMNAKDM4EHTTHSP90AA1 | |
| SCHEMBL10515648 | 0.72 | KDM4E (0.44) | MAPTLMNAKDM4EPOLBHTT | |
| SCHEMBL1143122 | 0.72 | KDM4E (0.46) | MAPTLMNAKDM4EHTTSMN1; SMN2 | |
| SCHEMBL17726533 | 0.72 | MGAM (0.42) | MAPTLMNAKDM4EHTTSMN1; SMN2 | |
| SCHEMBL7228171 | 0.71 | KDM4E (0.56) | MAPTLMNAKDM4EPOLBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330469-A2 | Tetrahydroisoquinoline derivatives | GLAXO GROUP LIMITED (GB) | 1989-08-30 | — | — | EP | disclosed |