Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1202228 | 0.92 | KDM4E (0.57) | KDM4EHSD17B10KMT2AMAOAALDH1A1 | |
| SCHEMBL1143224 | 0.83 | KDM4E (0.44) | KDM4EHSD17B10KMT2AMAOAALDH1A1 | |
| SCHEMBL10515648 | 0.80 | KDM4E (0.44) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL1143122 | 0.80 | KDM4E (0.46) | KDM4EHSD17B10KMT2AALDH1A1MAPT | |
| SCHEMBL4123425 | 0.75 | TSHR (0.43) | KDM4EKMT2AALDH1A1MAPTGAA | |
| SCHEMBL10517138 | 0.74 | MAPT (0.43) | KDM4EKMT2AMAPTNPSR1CYP1A2 | |
| SCHEMBL12071541 | 0.74 | MAOA (0.81) | KDM4EHSD17B10MAOAALDH1A1MAPT | |
| SCHEMBL4117558 | 0.74 | ALDH1A1 (0.51) | KDM4EHSD17B10KMT2AALDH1A1MAPT | |
| SCHEMBL18070225 | 0.72 | UGCG (0.47) | KDM4EHSD17B10KMT2AALDH1A1MAPT | |
| SCHEMBL27669711 | 0.70 | KDM4E (0.48) | KDM4EHSD17B10KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431564-B2 | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines | MERCK SHARP & DOHME B.V. (NL) | 2013-04-30 | — | — | US | disclosed |