SCHEMBL10517469

SCHEMBL10517469

Cc1nn(C)c2nc(C(C)C)c(CCl)c(-c3ccc(F)cc3)c12

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCGR P47871 19/20 0.45
S1PR2 O95136 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7799751 0.88 GCGR (0.60) GCGR
SCHEMBL10518455 0.84 GCGR (0.44) GCGR
SCHEMBL8021235 0.79 GCGR (0.42) GCGRS1PR2
SCHEMBL7791791 0.76 GCGR (0.40) GCGRS1PR2
SCHEMBL9384902 0.76 GCGR (0.47) GCGRS1PR2
SCHEMBL7791767 0.69 HMGCR (0.63)
SCHEMBL2931973 0.68 MAPK14 (0.53) GCGR
SCHEMBL9302679 0.68 S1PR2 (0.37) GCGRS1PR2
SCHEMBL9268564 0.67 GCGR (0.64) GCGR
SCHEMBL27885298 0.66 GCGR (0.49) GCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0327500-A2 5-Substituted 1H-pyrazolo[3,4-b]pyridine derivatives, their preparation and pharmaceutical compositions containing them SANDOZ AG (CH) 1989-08-09 EP disclosed
US-4822799-A Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals SANDOZ PHARM. CORP. (US) 1989-04-18 US disclosed