Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 6/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10517183 | 0.87 | LMNA (0.41) | LMNAHTTNPSR1SMN1; SMN2CCR1 | |
| SCHEMBL10518376 | 0.86 | HSD17B3 (0.44) | LMNAHTTNPSR1SMN1; SMN2CCR1 | |
| SCHEMBL10518982 | 0.86 | LMNA (0.38) | LMNAHTTNPSR1SMN1; SMN2CCR1 | |
| SCHEMBL10519242 | 0.84 | LMNA (0.39) | LMNAHTTNPSR1SMN1; SMN2CCR1 | |
| SCHEMBL10519086 | 0.83 | LMNA (0.36) | LMNAHTTNPSR1SMN1; SMN2CCR1 | |
| SCHEMBL10518197 | 0.80 | SLC6A4 (0.38) | LMNAHTTNPSR1HSD17B3CYP2D6 | |
| SCHEMBL10521688 | 0.72 | LMNA (0.36) | LMNACCR1HSD17B3CYP2D6SLC6A2 | |
| SCHEMBL13379763 | 0.71 | LMNA (0.48) | LMNAHTTNPSR1SMN1; SMN2CCR1 | |
| SCHEMBL10728041 | 0.71 | LMNA (0.37) | LMNAHTTNPSR1CCR1HSD17B3 | |
| SCHEMBL10723665 | 0.70 | LMNA (0.34) | LMNAHTTNPSR1CCR1HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189078-B1 | TRICYCLIC COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND METHOD OF TREATMENT THEREWITH | AB LEO (SE) | 1989-06-28 | — | — | EP | disclosed |
| US-4645758-A | Urinary incontinence ameliorating dibenz- b,e- -oxepin and -thiepin derivatives, compositions, and method of use therefor | AKTIEBOLAGET LEO (SE) | 1987-02-24 | — | — | US | disclosed |
| EP-0189078-A1 | Tricyclic compounds, compositions containing such compounds, processes for their preparation and method of treatment therewith | AB LEO (SE) | 1986-07-30 | — | — | EP | disclosed |