Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 7/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519242 | 0.92 | LMNA (0.39) | LMNAHTTNPSR1CCR1PDK2 | |
| SCHEMBL10517641 | 0.83 | LMNA (0.49) | LMNAHTTNPSR1CCR1SLC6A4 | |
| SCHEMBL10518982 | 0.82 | LMNA (0.38) | LMNAHTTNPSR1CCR1PDK2 | |
| SCHEMBL10517183 | 0.76 | LMNA (0.41) | LMNAHTTNPSR1CCR1PDK2 | |
| SCHEMBL10518376 | 0.75 | HSD17B3 (0.44) | LMNAHTTNPSR1CCR1PDK2 | |
| SCHEMBL10520758 | 0.71 | PDK2 (0.36) | CCR1PDK2SLC6A4 | |
| SCHEMBL10723665 | 0.68 | LMNA (0.34) | LMNAHTTNPSR1CCR1PDK2 | |
| SCHEMBL10692616 | 0.67 | TRPA1 (0.44) | DRD2 | |
| SCHEMBL10518073 | 0.66 | HTT (0.38) | LMNAHTTNPSR1CCR1PDK2 | |
| SCHEMBL10517740 | 0.66 | LMNA (0.46) | LMNAHTTNPSR1CCR1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189078-B1 | TRICYCLIC COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND METHOD OF TREATMENT THEREWITH | AB LEO (SE) | 1989-06-28 | — | — | EP | disclosed |
| US-4645758-A | Urinary incontinence ameliorating dibenz- b,e- -oxepin and -thiepin derivatives, compositions, and method of use therefor | AKTIEBOLAGET LEO (SE) | 1987-02-24 | — | — | US | disclosed |
| EP-0189078-A1 | Tricyclic compounds, compositions containing such compounds, processes for their preparation and method of treatment therewith | AB LEO (SE) | 1986-07-30 | — | — | EP | disclosed |