Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10633051 | 0.76 | CHEK2 (0.41) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL10632720 | 0.74 | SRC (0.44) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL10522462 | 0.71 | MEN1 (0.35) | MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL10639291 | 0.71 | KMT2A (0.33) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL17950473 | 0.66 | CDC7 (0.33) | MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL4757582 | 0.66 | ALDH1A1 (0.37) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL23327604 | 0.63 | MEN1 (0.39) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL10521662 | 0.62 | IKBKB (0.58) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL25170501 | 0.60 | PDPK1 (0.54) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL5435622 | 0.60 | KDM4E (0.60) | ALDH1A1HPGDKDM4EMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0177065-B1 | THIENOTRIAZINES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-03-29 | — | — | EP | claimed |
| EP-0177065-A1 | Thienotriazines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-09 | — | — | EP | claimed |
| US-4581448-A | Thienotriazines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-08 | — | — | US | claimed |
| EP-0177065-B1 | THIENOTRIAZINES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-03-29 | — | — | EP | disclosed |
| US-4581448-A | Thienotriazines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-08 | — | — | US | disclosed |