Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10998587 | 0.83 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1HPGDPDE3B | |
| SCHEMBL10639039 | 0.77 | SRC (0.38) | SRCMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL10633051 | 0.77 | CHEK2 (0.41) | MEN1KMT2AALDH1A1HPGDPDE3B | |
| SCHEMBL10520071 | 0.74 | MEN1 (0.41) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL10522462 | 0.72 | MEN1 (0.35) | MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL17950464 | 0.68 | PDE3A (0.50) | SRCMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL10635577 | 0.66 | KDM4E (0.59) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL23327604 | 0.65 | MEN1 (0.39) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL4757582 | 0.63 | ALDH1A1 (0.37) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL11546938 | 0.62 | SRC (0.62) | SRCALDH1A1HPGDPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126487-B1 | SUBSTITUTED 1,2,3-TRIAZINO(4',5':4,5)-THIENO(2,3-B)QUINOLINE-4(3H)-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-24 | — | — | EP | claimed |
| US-4496725-A | Substituted 1,2,3-triazino[4',5':4,5]-thieno[2,3-B]quinolin-4(3H)-ones | THE DOW CHEMICAL COMPANY (US) | 1985-01-29 | — | — | US | claimed |
| EP-0126487-A2 | Substituted 1,2,3-triazino(4',5':4,5)-thieno(2,3-b)quinoline-4(3H)-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-11-28 | — | — | EP | claimed |
| EP-0126487-B1 | SUBSTITUTED 1,2,3-TRIAZINO(4',5':4,5)-THIENO(2,3-B)QUINOLINE-4(3H)-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-24 | — | — | EP | disclosed |
| US-4496725-A | Substituted 1,2,3-triazino[4',5':4,5]-thieno[2,3-B]quinolin-4(3H)-ones | THE DOW CHEMICAL COMPANY (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0126487-A2 | Substituted 1,2,3-triazino(4',5':4,5)-thieno(2,3-b)quinoline-4(3H)-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-11-28 | — | — | EP | disclosed |