Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | BID | P55957 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10521472 | 0.99 | SIGMAR1 (0.52) | SIGMAR1PTGESALOX5PPARGHRH4 | |
| SCHEMBL10521941 | 0.95 | SIGMAR1 (0.53) | SIGMAR1PTGESALOX5PPARGHRH4 | |
| SCHEMBL10522911 | 0.84 | SIGMAR1 (0.49) | SIGMAR1PTGESALOX5PPARGHRH4 | |
| SCHEMBL7280252 | 0.83 | CTNNB1 (0.52) | HRH4FOLH1KMT2ACTNNB1TDP1 | |
| SCHEMBL7280245 | 0.83 | CTNNB1 (0.52) | HRH4FOLH1KMT2ACTNNB1TDP1 | |
| SCHEMBL5953914 | 0.82 | FOLH1 (0.66) | HRH4FOLH1CTNNB1TDP1 | |
| SCHEMBL1858161 | 0.82 | KMT2A (0.52) | SIGMAR1HRH4KMT2ACTNNB1GRIK1 | |
| SCHEMBL10522072 | 0.82 | HRH4 (0.50) | SIGMAR1PTGESALOX5PPARGHRH4 | |
| SCHEMBL7352579 | 0.82 | CYP1A2 (0.65) | PPARGHRH4FOLH1KMT2ACTNNB1 | |
| SCHEMBL10521559 | 0.81 | FOLH1 (0.68) | PTGESALOX5PPARGFOLH1GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |