Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5447508 | 0.73 | ALDH1A1 (0.36) | CTDSP1ALDH1A1PKMSMN1; SMN2CYP3A4 | |
| SCHEMBL2919397 | 0.66 | — | — | |
| SCHEMBL5421843 | 0.64 | ALDH1A1 (0.31) | ALDH1A1SMN1; SMN2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7491125 | 0.64 | — | — | |
| SCHEMBL7490975 | 0.63 | — | — | |
| SCHEMBL2114822 | 0.62 | CTDSP1 (0.49) | CTDSP1ALDH1A1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL4462216 | 0.61 | — | — | |
| SCHEMBL9265060 | 0.59 | — | — | |
| SCHEMBL7488301 | 0.59 | — | — | |
| SCHEMBL22651958 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4791199-A | Process for antiarrhythmic 1,3-diazabicyclo[4.4.0]dec-2-en-4-ones | G. D. SEARLE & CO. (US) | 1988-12-13 | — | — | US | claimed |
| EP-0215477-A1 | Process and intermediates for antiarrhytmic 1,3-diazabicyclo/4.4.0/dec-2-en-4-ones | G.D. Searle & Co. (US) | 1987-03-25 | — | — | EP | claimed |
| EP-0175319-B1 | HEXAHYDROINDOLIZINONES | G.D. Searle & Co. (US) | 1989-12-06 | — | — | EP | disclosed |
| US-4791199-A | Process for antiarrhythmic 1,3-diazabicyclo[4.4.0]dec-2-en-4-ones | G. D. SEARLE & CO. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4791199-A | Process for antiarrhythmic 1,3-diazabicyclo[4.4.0]dec-2-en-4-ones | G. D. SEARLE & CO. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4791199-A | Process for antiarrhythmic 1,3-diazabicyclo[4.4.0]dec-2-en-4-ones | G. D. SEARLE & CO. (US) | 1988-12-13 | — | — | US | disclosed |
| EP-0104647-B1 | PYRIDOPYRIMIDINONES | G.D. Searle & Co. (US) | 1988-03-30 | — | — | EP | disclosed |
| EP-0234331-A1 | Octahydropyrido[1,2-c]-pyrimidinones | G.D. Searle & Co. (US) | 1987-09-02 | — | — | EP | disclosed |
| US-4680295-A | ANTIARRHYTHMIA AGENTS | G. D. SEARLE & CO. (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0215477-A1 | Process and intermediates for antiarrhytmic 1,3-diazabicyclo/4.4.0/dec-2-en-4-ones | G.D. Searle & Co. (US) | 1987-03-25 | — | — | EP | disclosed |
| EP-0215477-A1 | Process and intermediates for antiarrhytmic 1,3-diazabicyclo/4.4.0/dec-2-en-4-ones | G.D. Searle & Co. (US) | 1987-03-25 | — | — | EP | disclosed |
| EP-0215477-A1 | Process and intermediates for antiarrhytmic 1,3-diazabicyclo/4.4.0/dec-2-en-4-ones | G.D. Searle & Co. (US) | 1987-03-25 | — | — | EP | disclosed |
| EP-0175319-A1 | Hexahydroindolizinones | G.D. Searle & Co. (US) | 1986-03-26 | — | — | EP | disclosed |
| US-4567270-A | Hexahydroindolizinones useful for treating cardiac arrhythmia, thrombotic disorders in mammals | G. D. SEARLE & CO. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4560754-A | Substituted 5-phenyl-5-(aminoalkyl)-1,3-diazabicyclo[4.4.0]decan-4-ones and 5-phenyl-5-(aminoalkyl)-1,3-diazabicyclo[4.4.0]dec-2-en-4-ones | G. D. SEARLE & CO. (US) | 1985-12-24 | — | — | US | disclosed |