⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5421843 | 0.98 | ALDH1A1 (0.31) | — | |
| SCHEMBL7488301 | 0.93 | — | — | |
| SCHEMBL7491125 | 0.80 | — | — | |
| SCHEMBL7490975 | 0.78 | — | — | |
| SCHEMBL22651958 | 0.74 | — | — | |
| SCHEMBL2670282 | 0.73 | — | — | |
| SCHEMBL9044557 | 0.73 | — | — | |
| SCHEMBL7490307 | 0.73 | CTDSP1 (0.32) | — | |
| SCHEMBL5376368 | 0.73 | — | — | |
| SCHEMBL10522115 | 0.66 | CTDSP1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12281101-B2 | Bicyclic lactams and methods of use thereof | GENENTECH, INC. (US) | 2025-04-22 | — | — | US | disclosed |
| US-20220348559-A1 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2022-11-03 | — | — | US | disclosed |
| WO-2020081838-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | Frequency Therapeutics, Inc. (US) | 2020-04-23 | — | — | WO | disclosed |
| EP-3044224-A1 | KETO-IMIDAZOPYRIDINE DERIVATIVES AS RORc MODULATORS | F. Hoffmann-La Roche AG (CH) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015036411-A1 | KETO-IMIDAZOPYRIDINE DERIVATIVES AS RORc MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-19 | — | — | WO | disclosed |
| EP-2004658-B1 | CONDENSED IMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS | NOVARTIS AG (CH) | 2010-10-13 | — | — | EP | disclosed |
| EP-2004657-B1 | CONDENSED IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2010-09-01 | — | — | EP | disclosed |
| US-20050058725-A1 | Combination therapy including a matrix metalloproteinase inhibitor and an antineoplastic agent | MCKEARN JOHN P (US) | 2005-03-17 | — | — | US | disclosed |
| EP-1201661-A1 | HETEROAROMATIC RING COMPOUNDS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2002-05-02 | — | — | EP | disclosed |
| EP-0445837-B1 | Crosslinkable polyester/isocyanate compositions suitable for the preparation of composite materials | SIR IND SPA (IT) | 1997-01-08 | — | — | EP | disclosed |
| EP-0445837-A2 | Crosslinkable polyester/isocyanate compositions suitable for the preparation of composite materials | Montedison S.p.A. (IT) | 1991-09-11 | — | — | EP | disclosed |
| US-4904792-A | N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds | ELI LILLY AND COMPANY (US) | 1990-02-27 | — | — | US | disclosed |
| US-4760075-A | Miticides | ELI LILLY AND COMPANY (US) | 1988-07-26 | — | — | US | disclosed |
| US-4474794-A | N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds | ELI LILLY AND COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| US-4468399-A | ANTISECRETORY AGENTS, ANTIHISTAMINES | ELI LILLY AND COMPANY (US) | 1984-08-28 | — | — | US | disclosed |
| US-4382090-A | N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds | ELI LILLY AND COMPANY (US) | 1983-05-03 | — | — | US | disclosed |
| US-4375547-A | ANTIHISTAMINES, 'I RECEPTOR ANTAGONISTS, ANTISECRETORY AGENTS | ELI LILLY AND COMPANY (US) | 1983-03-01 | — | — | US | disclosed |
| US-4307101-A | ANTIHISTAMINES AND ANTISECRETORY AGENTS OF THE THIOUREA OR UREA DERIVATIVES 5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-12-22 | — | — | US | disclosed |