Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 8/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 2/20 | 0.55 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5334421 | 0.93 | MAPT (0.63) | POLBMAPTHSD17B10TP53NPC1 | |
| SCHEMBL10523079 | 0.88 | HSD17B10 (0.58) | POLBMAPTHSD17B10TP53NPC1 | |
| Hydrochloric Acid SCHEMBL10520461 | 0.87 | HSD17B10 (0.57) | POLBMAPTHSD17B10TP53NPC1 | |
| Hydrochloric Acid SCHEMBL10523102 | 0.87 | HSD17B10 (0.57) | POLBMAPTHSD17B10TP53NPC1 | |
| Hydrochloric Acid SCHEMBL10525312 | 0.86 | HSD17B10 (0.56) | POLBMAPTHSD17B10TP53NPC1 | |
| Hydrochloric Acid SCHEMBL10521981 | 0.83 | HSD17B10 (0.58) | POLBMAPTHSD17B10TP53NPC1 | |
| Hydrochloric Acid SCHEMBL10520762 | 0.83 | HTR6 (0.64) | POLBMAPTHSD17B10TP53NPC1 | |
| Hydrochloric Acid SCHEMBL10522484 | 0.82 | HTR6 (0.62) | POLBMAPTHSD17B10TP53NPC1 | |
| SCHEMBL10521905 | 0.78 | POLB (0.55) | POLBMAPTHSD17B10TP53NPC1 | |
| SCHEMBL18038659 | 0.75 | MAPT (0.93) | POLBMAPTHSD17B10TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4876267-A | MIGRANES | GLAXO GROUP LIMITED (GB) | 1989-10-24 | — | — | US | disclosed |
| EP-0254433-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1988-01-27 | — | — | EP | disclosed |