SCHEMBL10522648

SCHEMBL10522648

C=CCOc1nc(Cl)nc(NC(C)(C)CCCCC)n1

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.35
PDE4A P27815 5/20 0.34
LMNA P02545 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
MAPT P10636 2/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C19 P33261 1/20 0.31
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10522655 0.82 LMNA (0.37) KMT2APDE4ALMNASMN1; SMN2MAPT
SCHEMBL9391104 0.80 LMNA (0.52) KMT2APDE4ALMNASMN1; SMN2MAPT
SCHEMBL39223 0.80 KMT2A (0.47) KMT2APDE4ALMNASMN1; SMN2CYP1A2
SCHEMBL10898092 0.77
SCHEMBL10900695 0.77 NPSR1 (0.38)
SCHEMBL10522533 0.76 KMT2A (0.35) KMT2APDE4ALMNASMN1; SMN2MAPT
SCHEMBL10523394 0.73
SCHEMBL10522923 0.72
SCHEMBL4303477 0.72 KMT2A (0.38) KMT2APDE4ALMNASMN1; SMN2MAPT
SCHEMBL10444895 0.71 KMT2A (0.36) KMT2APDE4ALMNASMN1; SMN2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0070386-B1 NOVEL LIGHT STABILIZERS FOR POLYMERS AMERICAN CYANAMID COMPANY (US) 1989-01-11 EP disclosed
EP-0082244-B1 NOVEL LIGHT STABILIZERS FOR POLYMERS AMERICAN CYANAMID COMPANY (US) 1986-03-19 EP disclosed
US-4461861-A Polymer compositions stabilized with triazinyl-piperidine compounds AMERICAN CYANAMID COMPANY (US) 1984-07-24 US disclosed
US-4400505-A Triazinyl-piperidines as light stabilizers for polymers AMERICAN CYANAMID COMPANY (US) 1983-08-23 US disclosed
EP-0082244-A1 Novel light stabilizers for polymers AMERICAN CYANAMID COMPANY (US) 1983-06-29 EP disclosed
EP-0070386-A1 Novel light stabilizers for polymers AMERICAN CYANAMID COMPANY (US) 1983-01-26 EP disclosed