Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 5/20 | 0.71 |
| ▸ | GABBR1 | Q9UBS5 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | WRN | Q14191 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Amino-3- (5-Chlorothien-2-Yl)Butanoic Acid SCHEMBL342009 | 0.83 | GABBR2 (1.00) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL27697147 | 0.76 | GABBR2 (0.66) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL4034402 | 0.70 | GABBR2 (0.69) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL16680588 | 0.68 | GABBR2 (0.51) | GABBR2GABBR1LMNACYP3A4CYP2D6 | |
| SCHEMBL23972469 | 0.67 | GABBR2 (0.50) | GABBR2GABBR1LMNACYP3A4BLM | |
| SCHEMBL8536948 | 0.67 | GABBR2 (0.66) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL15952208 | 0.67 | GABBR2 (0.46) | GABBR2GABBR1CYP3A4CYP2D6DAO | |
| SCHEMBL20032385 | 0.66 | GABBR2 (0.49) | GABBR2GABBR1CYP3A4CYP2D6MEN1 | |
| SCHEMBL5212433 | 0.66 | GABBR2 (0.53) | GABBR2GABBR1CYP2C9CYP3A4DRD3 | |
| SCHEMBL4392686 | 0.66 | GABBR2 (0.49) | GABBR2GABBR1TSHRDAOGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593104-A2 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | Müller, Prof. Dr., Wolfgang (DE) | 2013-05-22 | — | — | EP | claimed |
| WO-2011011692-A2 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | STC.UNM (US) | 2011-01-27 | — | — | WO | claimed |