4-Amino-3- (5-Chlorothien-2-Yl)Butanoic Acid

4-Amino-3- (5-Chlorothien-2-Yl)Butanoic Acid

SCHEMBL342009

NCC(CC(=O)O)c1ccc(Cl)s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GABBR2 O75899 5/20 1.00
GABBR1 Q9UBS5 5/20 1.00
LMNA P02545 2/20 0.54
CYP2C9 P11712 2/20 0.54
CYP3A4 P08684 1/20 0.54
ADORA3 P0DMS8 1/20 0.54
NFKB1 P19838 1/20 0.54
DRD3 P35462 1/20 0.54
BLM P54132 1/20 0.54
CYP1A2 P05177 1/20 0.54
CYP2D6 P10635 1/20 0.54
CYP2C19 P33261 1/20 0.54
MEN1 O00255 1/20 0.54
THRB P10828 1/20 0.54
TSHR P16473 1/20 0.54
KMT2A Q03164 1/20 0.54
F2 P00734 1/20 0.39
DAO P14920 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1052288 0.83 GABBR2 (0.71) GABBR2GABBR1LMNACYP2C9CYP3A4
SCHEMBL340904 0.80 GABBR2 (0.67) GABBR2GABBR1LMNACYP2C9CYP3A4
SCHEMBL341475 0.80 GABBR2 (0.67) GABBR2GABBR1LMNACYP2C9CYP3A4
SCHEMBL27697147 0.79 GABBR2 (0.66) GABBR2GABBR1LMNACYP2C9CYP3A4
SCHEMBL9202497 0.75 GABBR2 (0.60) GABBR2GABBR1LMNACYP2C9CYP3A4
SCHEMBL4306120 0.73 GABBR2 (0.57) GABBR2GABBR1LMNACYP2C9CYP3A4
SCHEMBL27740304 0.72 GABBR2 (0.56) GABBR2GABBR1LMNACYP2C9CYP3A4
SCHEMBL341042 0.71 GABBR2 (0.56) GABBR2GABBR1LMNACYP2C9CYP3A4
SCHEMBL17459297 0.71 GABBR2 (0.54) GABBR2GABBR1LMNACYP3A4ADORA3
Baclofen SCHEMBL5556250 0.70 GABBR2 (1.00) GABBR2GABBR1LMNACYP2C9CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 158 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200182859-A1 HDAC1/2 ACTIVATOR FOR PROMOTING AND/OR ACCELERATING MYELINATION AND/OR REMYELINATION UNIVERSITE DE FRIBOURG (CH) 2020-06-11 US claimed
EP-3634421-A1 HDAC1/2 ACTIVATOR FOR PROMOTING AND/OR ACCELERATING MYELINATION AND/OR REMYELINATION Université de Fribourg (CH) 2020-04-15 EP claimed
US-20190167632-A1 METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) MUELLER WOLFGANG S (US) 2019-06-06 US claimed
US-20190125779-A1 PHARMACEUTICAL COMPOSITIONS UNIVERSITY OF HOUSTON SYSTEM (US) 2019-05-02 US claimed
US-10238622-B2 Methods of treating and preventing/reducing the likelihood of Mesial temporal lobe epilepsy (TLE) THE REGENTS OF THE UNIVERSITY OF NEW MEXICO 2019-03-26 US claimed
WO-2018224650-A1 HDAC1/2 ACTIVATOR FOR PROMOTING AND/OR ACCELERATING MYELINATION AND/OR REMYELINATION UNIVERSITE DE FRIBOURG (CH) 2018-12-13 WO claimed
EP-3412294-A1 HDAC1/2 ACTIVATOR FOR PROMOTING AND/OR ACCELERATING MYELINATION AND/OR REMYELINATION Universite De Fribourg (CH) 2018-12-12 EP claimed
US-20170042929-A9 Methods of Treating Neurological Diseases UNIVERSITY OF HOUSTON 2017-02-16 US claimed
WO-2016109624-A1 PHARMACEUTICAL COMPOSITIONS UNIVERSITY OF HOUSTON SYSTEM (US) 2016-07-07 WO claimed
US-20150051166-A1 Methods of Treating Neurological Diseases ZIBURKUS JOKUBAS (US) 2015-02-19 US claimed
WO-2004105795-A1 PHARMACEUTICAL COMBINATIONS OF A PROTON PUMP INHIBITOR AND A COMPOUND WHICH MODIFIES GASTROINTESTINAL MOTILITY ALTANA PHARMA AG (DE) 2004-12-09 WO claimed
EP-1344524-A1 Reflux inhibitors AstraZeneca AB (SE) 2003-09-17 EP claimed
EP-0936906-B1 REFLUX INHIBITORS ASTRAZENECA AB (SE) 2003-09-10 EP claimed
US-20030162754-A1 Use of GABA and GABAB agonists TUFTS UNIVERSITY 2003-08-28 US claimed
CN-1117560-C Reflux inhibitors ASTRA AB (SE) 2003-08-13 CN claimed
US-6117908-A Use of GABAB receptor agonists as reflux inhibitors ASTRA AKTIEBOLAG (SE) 2000-09-12 US claimed
WO-1999063935-A2 RAPID OPIOID DETOXIFICATION THERAPY AND ANTI-READDICTION THERAPY U.S. DETOX, INC. (US) 1999-12-16 WO claimed
CN-1237105-A Reflux inhibitors ASTRA AB (SE) 1999-12-01 CN claimed
EP-0936906-A1 REFLUX INHIBITORS Astra Aktiebolag (SE) 1999-08-25 EP claimed
WO-1998011885-A1 REFLUX INHIBITORS ASTRA AKTIEBOLAG (SE) 1998-03-26 WO claimed