Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.88 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.50 |
| ▸ | TET3 | O43151 | 2/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 2/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL95333 | 0.97 | SMN1; SMN2 (0.94) | SMN1; SMN2TET2TET3SLC22A6TET1 | |
| Malic Acid SCHEMBL29008105 | 0.97 | SMN1; SMN2 (0.94) | SMN1; SMN2TET2TET3SLC22A6TET1 | |
| Malic Acid SCHEMBL733142 | 0.97 | SMN1; SMN2 (0.94) | SMN1; SMN2TET2TET3SLC22A6TET1 | |
| Malic Acid SCHEMBL20339816 | 0.97 | SMN1; SMN2 (0.94) | SMN1; SMN2TET2TET3SLC22A6TET1 | |
| Malic Acid SCHEMBL29008345 | 0.94 | SMN1; SMN2 (0.88) | SMN1; SMN2TET2TET3SLC22A6TET1 | |
| Malic Acid SCHEMBL5427117 | 0.94 | SMN1; SMN2 (0.88) | SMN1; SMN2TET2TET3SLC22A6TET1 | |
| Malic Acid SCHEMBL11502487 | 0.94 | SMN1; SMN2 (0.88) | SMN1; SMN2TET2TET3SLC22A6TET1 | |
| Malic Acid SCHEMBL9478094 | 0.94 | SMN1; SMN2 (0.88) | SMN1; SMN2TET2TET3SLC22A6TET1 | |
| Malic Acid SCHEMBL98496 | 0.94 | — | — | |
| Malic Acid SCHEMBL14125844 | 0.94 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3SLC22A6TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822917-A | USING CATALYST OF RHODIUM COMPOUND AND TRIVALENT PHOSPHORUS COMPOUND | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0272608-A1 | Process for the hydroformylation of an olefin | MITSUBISHI KASEI CORPORATION (JP) | 1988-06-29 | — | — | EP | disclosed |
| US-4528403-A | Hydroformylation process for preparation of aldehydes and alcohols | MITSUBISHI CHEMICAL INDUSTRIES LTD. (JP) | 1985-07-09 | — | — | US | disclosed |