Malic Acid

Malic Acid

SCHEMBL95333

O=C(O)CC(O)C(=O)O.[KH]

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F

The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.94
SLC22A6 Q4U2R8 1/20 0.53
TET2 Q6N021 6/20 0.52
TET3 O43151 2/20 0.52
TET1 Q8NFU7 1/20 0.52
KDM4A O75164 2/20 0.50
KDM4C Q9H3R0 2/20 0.50
KDM2A Q9Y2K7 2/20 0.50
OR51E2 Q9H255 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
GABRR1 P24046 2/20 0.43
LMNA P02545 1/20 0.43
KMO O15229 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Malic Acid SCHEMBL29008105 1.00 SMN1; SMN2 (0.94) SMN1; SMN2SLC22A6TET2TET3TET1
Malic Acid SCHEMBL733142 1.00 SMN1; SMN2 (0.94) SMN1; SMN2SLC22A6TET2TET3TET1
Malic Acid SCHEMBL20339816 1.00 SMN1; SMN2 (0.94) SMN1; SMN2SLC22A6TET2TET3TET1
Malic Acid SCHEMBL11502487 0.97 SMN1; SMN2 (0.88) SMN1; SMN2SLC22A6TET2TET3TET1
Malic Acid SCHEMBL10524028 0.97 SMN1; SMN2 (0.88) SMN1; SMN2SLC22A6TET2TET3TET1
Malic Acid SCHEMBL9478094 0.97 SMN1; SMN2 (0.88) SMN1; SMN2SLC22A6TET2TET3TET1
Malic Acid SCHEMBL5427117 0.97 SMN1; SMN2 (0.88) SMN1; SMN2SLC22A6TET2TET3TET1
Malic Acid SCHEMBL29008345 0.97 SMN1; SMN2 (0.88) SMN1; SMN2SLC22A6TET2TET3TET1
Malic Acid SCHEMBL856 0.97
Malic Acid SCHEMBL14125844 0.97 SMN1; SMN2 (1.00) SMN1; SMN2SLC22A6TET2TET3TET1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3234 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117898467-B Cigarette design and preparation method based on mouth-by-mouth dynamic smoking resistance and cigarette density 浙江中烟工业有限责任公司 2026-05-15 CN claimed
CN-122010160-A Method for synthesizing calcium sulfate nanorod by morphology regulation and control of waste gypsum, calcium sulfate nanorod and application thereof, supported aromatic nitro hydrogenation catalyst and preparation method thereof 中南大学 2026-05-12 CN claimed
US-20260069910-A1 ENVIRONMENTALLY-CLEAN WATER-BASED FIRE INHIBITING BIOCHEMICAL SOLUTIONS AND METHODS OF AND APPARATUS FOR APPLYING THE SAME TO PROTECT PROPERTY AGAINST WILDFIRE MIGHTY FIRE BREAKER LLC (US) 2026-03-12 US claimed
US-20260070797-A1 PREPARATION METHOD AND USE OF FUNCTION TYPE ACTIVE ALUMINOSILICATE FUZHOU UNIVERSITY (CN) 2026-03-12 US claimed
US-20260069911-A1 ENVIRONMENTALLY-CLEAN FIRE INHIBITING BIOCHEMICAL COMPOSITIONS, SOLUTIONS AND POWDERS, AND METHODS OF AND APPARATUS FOR PRODUCING FIRE PROTECTED WOOD PRODUCTS MIGHTY FIRE BREAKER LLC (US) 2026-03-12 US claimed
US-20260048289-A1 ENVIRONMENTALLY-SAFE WATER-BASED FIRE RETARDANT BIOCHEMICAL COMPOSITIONS FORMULATED USING ALKALI METAL SALTS, FREE FROM PHOSPHATES, NITRATES, AND AMMONIUM-SALTS, FOR NON-CORROSIVE AERIAL AND GROUND DELIVERY ONTO PROPERTY REQUIRING LONG-TERM PROTECTION AGAINST WILDFIRE MIGHTY FIRE BREAKER LLC (US) 2026-02-19 US claimed
EP-4687476-A1 HOLLOW FIBRES IP Ventures GmbH (CH) 2026-02-11 EP claimed
US-20260014404-A1 LONG-TERM FIRE RETARDANT WITH CORROSION INHIBITORS AND METHODS FOR MAKING AND USING SAME PERIMETER SOLUTIONS, LP (US) 2026-01-15 US claimed
US-20260014403-A1 ENVIRONMENTALLY-CLEAN WATER-BASED FIRE INHIBITING BIOCHEMICAL COMPOSITIONS, SOLUTIONS, POWDERS AND METHODS OF AND APPARATUS FOR PRODUCING FIRE PROTECTED WOOD AND ENGINEERED WOOD PRODUCTS MIGHTY FIRE BREAKER LLC (US) 2026-01-15 US claimed
WO-2025264733-A1 LONG-TERM FIRE RETARDANT WITH CORROSION INHIBITORS AND METHODS FOR MAKING AND USING SAME PERIMETER SOLUTIONS, LP (US) 2025-12-26 WO claimed
US-5261425-A Cigarette R. J. REYNOLDS TOBACCO COMPANY (US) 1993-11-16 US claimed
US-5141007-A Cigarette R. J. REYNOLDS TOBACCO COMPANY (US) 1992-08-25 US claimed
US-5120801-A Impact strength, ductility GENERAL ELECTRIC CO. (US) 1992-06-09 US claimed
US-5050622-A Cigarette R. J. REYNOLDS TOBACCO COMPANY (US) 1991-09-24 US claimed
US-5000897-A Copolymerization of polyamides and polyethers after blending for improved impact strength GENERAL ELECTRIC COMPANY (US) 1991-03-19 US claimed
US-4581235-A YEAST, AN EDIBLE ACID, A BUFFER A NITROGEN PRODUCING COMPOUND, ANDFLAVORINGS Hoskins, George W. (CA) 1986-04-08 US claimed
US-4506684-A PRECIPITATION OF METAL SALTS PHILIP MORRIS INCORPORATED (US) 1985-03-26 US claimed
US-4406882-A GLYCYRRHETINIC ACID, ESTER DERIVATIVES BIOREX LABORATORIES LIMITED (GB) 1983-09-27 US claimed
US-4215040-A RECOVERING VEGETABLE SEED PROTEIN USING ORGANIC CARBOXYLIC ACID SALT THE PROCTER & GAMBLE COMPANY (US) 1980-07-29 US claimed
US-4066793-A Seasoning composition and preparation thereof AJINOMOTO CO., INC. (JA) 1978-01-03 US claimed