Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL29008105 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL95333 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL20339816 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL11502487 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL10524028 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL9478094 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL5427117 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL29008345 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL856 | 0.97 | — | — | |
| Malic Acid SCHEMBL14125844 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260014404-A1 | LONG-TERM FIRE RETARDANT WITH CORROSION INHIBITORS AND METHODS FOR MAKING AND USING SAME | PERIMETER SOLUTIONS, LP (US) | 2026-01-15 | — | — | US | claimed |
| WO-2025264733-A1 | LONG-TERM FIRE RETARDANT WITH CORROSION INHIBITORS AND METHODS FOR MAKING AND USING SAME | PERIMETER SOLUTIONS, LP (US) | 2025-12-26 | — | — | WO | claimed |
| CN-114436812-B | Preparation method of dipotassium malate | 河南瑞贝佳生物科技有限公司 | 2024-07-16 | — | — | CN | claimed |
| CN-118064905-A | Electrolyte modification and electrolyte for prolonging service life of alkaline electrolyzed seawater electrode and application | 中国科学院大连化学物理研究所 | 2024-05-24 | — | — | CN | claimed |
| WO-2023191907-A1 | LONG-TERM FIRE RETARDANT WITH CORROSION INHIBITORS AND METHODS FOR MAKING AND USING SAME | FRS GROUP, LLC (US) | 2023-10-05 | — | — | WO | claimed |
| CN-116669434-A | Tin oxide electron transport layer modified in situ by aliphatic carboxylic acid potassium salt, high-performance photovoltaic cell and preparation method thereof | 武汉理工大学 | 2023-08-29 | — | — | CN | claimed |
| CN-114436812-A | Preparation method of dipotassium malate | 河南瑞贝佳生物科技有限公司 | 2022-05-06 | — | — | CN | claimed |
| US-8420151-B2 | Mixtures having a salty taste | SYMRISE AG (DE) | 2013-04-16 | — | — | US | claimed |
| WO-2012143794-A1 | POLYMER STABILIZER SYSTEM FOR POLYMERS CONTAINING HALOGEN | GALATA CHEMICALS GMBH (DE) | 2012-10-26 | — | — | WO | claimed |
| EP-1937089-B1 | MIXTURES HAVING A SALTY TASTE | SYMRISE AG (DE) | 2012-08-22 | — | — | EP | claimed |
| US-20090214728-A1 | MIXTURES HAVING A SALTY TASTE | SYMRISE GMBH & CO. KG (DE) | 2009-08-27 | — | — | US | claimed |
| US-20080260948-A1 | INK AND INK JET RECORDING METHOD | CANON KABUSHIKI KAISHA (JP) | 2008-10-23 | — | — | US | claimed |
| EP-1937089-A1 | MIXTURES HAVING A SALTY TASTE | Symrise GmbH & Co. KG (DE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007045566-A1 | MIXTURES HAVING A SALTY TASTE | SYMRISE GMBH & CO. KG (DE) | 2007-04-26 | — | — | WO | claimed |
| US-5895525-A | ALKALI METAL MALATE OR CITRAMALATE SALT ACCELERATOR AND CALCIUM ALUMINUM SILICATE HYDRAULIC CEMENT; SHOTCRETING | MBT HOLDING AG (CH) | 1999-04-20 | — | — | US | claimed |
| US-5591259-A | MIXING WITH MALATE OR CITRAMALATE ACCELERATOR | SANDOZ LTD. (CH) | 1997-01-07 | — | — | US | claimed |
| WO-2026105439-A1 | LEATHER SURFACE TREATMENT AGENT AND LEATHER TREATED USING SAME | 日華化学株式会社 | 2026-05-21 | — | — | WO | disclosed |
| WO-2026098867-A1 | OXIDATIVE HAIR BRIGHTENING BY MEANS OF PERSULFATE, DICARBOXYLIC ACID, AND CITRULLINE | HENKEL AG & CO. KGAA (DE) | 2026-05-15 | — | — | WO | disclosed |
| US-4460723-A | STABILIZATION WITH ACID SALTS ALONE AND WITH RUBBER ADDITIONS | PHILLIPS PETROLEUM COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4330484-A | Diastereomeric salts of malic acid and 2-aminobutanol, and process for the resolution of rademis maic acid | BASF AKTIENGESELLSCHAFT (DE) | 1982-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260014404-A1 | LONG-TERM FIRE RETARDANT WITH CORROSION INHIBITORS AND METHODS FOR MAKING AND USING SAME | SLC6A12, SLC11A2, KCNN1 | SMN1; SMN2 2997/4885SLC22A6 274/4885TET2 1451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.