SCHEMBL105261

SCHEMBL105261

CC(C)c1ccc(O)c(Cl)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.57
ALOX12 P18054 2/20 0.57
HTT P42858 2/20 0.57
HIF1A Q16665 2/20 0.57
GAA P10253 1/20 0.57
TYR P14679 3/20 0.54
PTGS1 P23219 2/20 0.54
TRPA1 O75762 1/20 0.54
CACNA1C Q13936 1/20 0.54
RNASEH1 O60930 1/20 0.53
TSHR P16473 2/20 0.50
HSD17B10 Q99714 2/20 0.50
ESR2 Q92731 3/20 0.47
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
KDM4E B2RXH2 3/20 0.44
TDP1 Q9NUW8 3/20 0.44
MAPT P10636 2/20 0.44
ALOX15 P16050 2/20 0.44
MDM4 O15151 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31716485 0.86 HSD17B10 (0.50) ALDH1A1ALOX12HTTHIF1AGAA
SCHEMBL502532 0.86 HSD17B10 (0.50) ALDH1A1ALOX12HTTHIF1AGAA
SCHEMBL11789449 0.84 TSHR (0.48) ALDH1A1ALOX12HTTHIF1AGAA
SCHEMBL11357081 0.83 HSD17B10 (0.46) ALDH1A1ALOX12HTTHIF1AGAA
SCHEMBL20666764 0.83 HSD17B10 (0.46) ALDH1A1ALOX12HTTHIF1AGAA
SCHEMBL1493888 0.82 PTGS1 (0.59) ALDH1A1ALOX12HTTHIF1AGAA
SCHEMBL1596005 0.81 HSD17B10 (0.54) ALDH1A1ALOX12HIF1ATYRTSHR
SCHEMBL29465800 0.81 HSD17B10 (0.54) ALDH1A1ALOX12HIF1ATYRTSHR
SCHEMBL4458922 0.81 HSD17B10 (0.54) ALDH1A1ALOX12HIF1ATYRTSHR
SCHEMBL30343463 0.81 HSD17B10 (0.54) ALDH1A1ALOX12HIF1ATYRTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122037020-A Supported catalyst, preparation method thereof and application thereof in olefin polymerization 中国石油化工股份有限公司 2026-05-15 CN claimed
US-3954889-A Process for the production of 1,1,3,3-substituted hydroxyindanes BAYER AKTIENGESELLSCHAFT (DT) 1976-05-04 US claimed
CN-122037020-A Supported catalyst, preparation method thereof and application thereof in olefin polymerization 中国石油化工股份有限公司 2026-05-15 CN disclosed
CN-112679635-B Preparation method of supported metallocene catalyst and catalyst prepared by preparation method 中国石油化工股份有限公司 2024-03-26 CN disclosed
WO-2023009833-A9 MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2023-11-23 WO disclosed
US-20230287009-A1 OXO-SUBSTITUTED COMPOUND Sumitomo Pharma Co., Ltd. (JP) 2023-09-14 US disclosed
US-20230287009-A1 OXO-SUBSTITUTED COMPOUND Sumitomo Pharma Co., Ltd. (JP) 2023-09-14 US disclosed
WO-2023150601-A2 MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2023-08-10 WO disclosed
US-11702431-B2 Oxo-substituted compound Sumitomo Pharma Co., Ltd. (JP) 2023-07-18 US disclosed
US-11702431-B2 Oxo-substituted compound Sumitomo Pharma Co., Ltd. (JP) 2023-07-18 US disclosed
WO-2023118576-A1 DHODH INHIBITORS CONTAINING A CARBOXYLIC ACID BIOISOSTERE IMMUNIC AG (DE) 2023-06-29 WO disclosed
CN-100378165-C Epoxy resin composition for encapsulating optical semiconductor CHANGCHUN ARTIFICIAL RESIN FAC (CN) 2008-04-02 CN disclosed
WO-2007064797-A2 INHIBITORS OF C-MET AND USES THEREOF VERTEX PHARMACEUTICALS INCORPORATED (US) 2007-06-07 WO disclosed
US-7169785-B2 Methods and compositions of novel triazine compounds REDDY US THERAPEUTICS, INC. (US) 2007-01-30 US disclosed
WO-2006012504-A2 COMPOUNDS AND METHODS FOR TREATMENT OF THROMBOSIS DAIAMED, INC. (US) 2006-02-02 WO disclosed
CN-1613910-A Epoxy resin composition for encapsulating optical semiconductor CHANGCHUN ARTIFICIAL RESIN FAC (CN) 2005-05-11 CN disclosed
US-20040254305-A1 Epoxy resin composition for photosemiconductor package CHANG CHUN PLASTIC CO., LTD. (TW) 2004-12-16 US disclosed
US-4370505-A 1,1,3,3-Substituted hydroxyindanes BAYER AKTIENGESELLSCHAFT (DE) 1983-01-25 US disclosed
US-3983292-A Pressure sensitive recording papers SANKO CHEMICAL COMPANY LTD. (JA) 1976-09-28 US disclosed
US-3954889-A Process for the production of 1,1,3,3-substituted hydroxyindanes BAYER AKTIENGESELLSCHAFT (DT) 1976-05-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11702431-B2 Oxo-substituted compound CYP51A1, OXA1L, O60361 ALDH1A1 473/4885ALOX12 297/4885HTT 4871/4885
US-20230287009-A1 OXO-SUBSTITUTED COMPOUND CYP51A1, OXA1L, O60361 ALDH1A1 473/4885ALOX12 297/4885HTT 4871/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.