Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | S100A4 | P26447 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14579653 | 0.84 | TLR2 (0.44) | TLR2ERN1TLR1TLR6IMPDH2 | |
| SCHEMBL10869346 | 0.82 | MEN1 (0.34) | CYP2A6MEN1KMT2AESR1ESR2 | |
| SCHEMBL14579654 | 0.81 | IDO1 (0.53) | IMPDH2IMPDH1IDO1ALDH1A1EP300 | |
| SCHEMBL9050322 | 0.81 | ERN1 (0.37) | TLR2ERN1TLR1TLR6IMPDH2 | |
| SCHEMBL10530121 | 0.75 | AKR1B10 (0.37) | TLR2ERN1TLR1TLR6IMPDH2 | |
| SCHEMBL17291109 | 0.74 | MAPT (0.38) | IMPDH2IMPDH1IDO1ALDH1A1EP300 | |
| SCHEMBL9806325 | 0.72 | IMPDH2 (0.62) | IMPDH2IMPDH1ALDH1A1MAPTUSP2 | |
| SCHEMBL27398971 | 0.72 | CYP1A2 (0.52) | ALDH1A1CYP2A6HPGDMAPTMEN1 | |
| SCHEMBL10527760 | 0.71 | CDC25B (0.55) | ALDH1A1HPGDMAPTKMT2ACA12 | |
| SCHEMBL97371 | 0.70 | CA1 (0.62) | TLR2ERN1TLR1TLR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0182499-B1 | N-(6-METHOXY-5-(PERFLUOROALKYL)-1-NAPHTOLYL)-N-METYLGLYCINES AND THEIR THIONAPHTHOYL ANALOGS | AYERST, MCKENNA AND HARRISON INC. (CA) | 1989-04-12 | — | — | EP | claimed |
| EP-0182499-B1 | N-(6-METHOXY-5-(PERFLUOROALKYL)-1-NAPHTOLYL)-N-METYLGLYCINES AND THEIR THIONAPHTHOYL ANALOGS | AYERST, MCKENNA AND HARRISON INC. (CA) | 1989-04-12 | — | — | EP | disclosed |
| US-4604406-A | ALDOSE REDUCTASE INHIBITORS | AYERST, MCKENNA & HARRISON, INC. (CA) | 1986-08-05 | — | — | US | disclosed |
| EP-0182499-A1 | N-(6-methoxy-5-(perfluoroalkyl)-1-naphtolyl)-N-metylglycines and their thionaphthoyl analogs | AYERST, MCKENNA AND HARRISON INC. (CA) | 1986-05-28 | — | — | EP | disclosed |