Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CPS1 | P31327 | 10/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3850385 | 0.86 | RAB9A (0.53) | RAB9AALDH1A1MAPTLMNAKDM4E | |
| Bromide SCHEMBL10528522 | 0.84 | KMT2A (0.47) | RAB9AALDH1A1MAPTLMNAKDM4E | |
| Bromide SCHEMBL3853194 | 0.79 | ALDH1A1 (0.56) | RAB9AALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL28841407 | 0.78 | ALDH1A1 (0.54) | RAB9AALDH1A1MAPTLMNAKDM4E | |
| Bromide SCHEMBL3853590 | 0.78 | NPC1 (0.53) | RAB9AALDH1A1MAPTLMNAKDM4E | |
| Bromide SCHEMBL10526720 | 0.78 | NPC1 (0.53) | RAB9AALDH1A1MAPTLMNAKDM4E | |
| Bromide SCHEMBL10528514 | 0.77 | MAPT (0.40) | RAB9AALDH1A1MAPTALOX15LMNA | |
| SCHEMBL10531109 | 0.76 | MAPT (0.51) | RAB9AALDH1A1MAPTKDM4E | |
| Iodide SCHEMBL10531088 | 0.75 | MAPT (0.50) | RAB9AALDH1A1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL10528594 | 0.75 | MAPT (0.50) | RAB9AALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0182533-B1 | 3-(2-ARYL-2-OXOETHYL)-IMIDAZOLIUM SALTS AS HYPOGLYCEMIC AGENTS | ELI LILLY AND COMPANY (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4683312-A | ANTIDIABETIC AGENTS | ELI LILLY AND COMPANY (US) | 1987-07-28 | — | — | US | disclosed |
| US-4609670-A | ANTIDIABETIC AGENTS | ELI LILLY AND COMPANY (US) | 1986-09-02 | — | — | US | disclosed |
| EP-0182533-A2 | 3-(2-Aryl-2-oxoethyl)-imidazolium salts as hypoglycemic agents | ELI LILLY AND COMPANY (US) | 1986-05-28 | — | — | EP | disclosed |