Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 14/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 3/20 | 0.54 |
| ▸ | CA1 | P00915 | 3/20 | 0.54 |
| ▸ | CA9 | Q16790 | 3/20 | 0.54 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.49 |
| ▸ | GSTP1 | P09211 | 3/20 | 0.47 |
| ▸ | GSTM2 | P28161 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10528943 | 0.92 | CA2 (1.00) | CA2ALDH1A1CA12CA1CA9 | |
| SCHEMBL6114282 | 0.80 | CA2 (0.70) | CA2ALDH1A1CA12CA1CA9 | |
| SCHEMBL2831588 | 0.77 | CA2 (0.66) | CA2ALDH1A1CA12CA1CA9 | |
| SCHEMBL9877839 | 0.77 | CA2 (0.73) | CA2ALDH1A1GSTP1GSTM2SMN1; SMN2 | |
| SCHEMBL10528739 | 0.77 | CA2 (1.00) | CA2CA12CA1CA9 | |
| SCHEMBL1700058 | 0.76 | CA2 (0.64) | CA2ALDH1A1CA12CA1CA9 | |
| SCHEMBL10528804 | 0.74 | CA2 (0.66) | CA2CA12CA1CA9VCAM1 | |
| SCHEMBL10529657 | 0.73 | CA2 (1.00) | CA2ALDH1A1 | |
| SCHEMBL11876450 | 0.73 | CA2 (0.68) | CA2ALDH1A1GSTP1GSTM2 | |
| SCHEMBL6851577 | 0.71 | MAPT (0.66) | CA2ALDH1A1CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219429-B1 | SUBSTITUTED BENZENESULFONAMIDE AND ANTIGLAUCOMA FORMULATIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4678855-A | CARBONIC ANHYDRASE INHIBITORS, GLAUCOMA | MERCK & CO., INC. (US) | 1987-07-07 | — | — | US | disclosed |
| EP-0219429-A1 | Substituted benzenesulfonamide and antiglaucoma formulations containing them | MERCK & CO. INC. (US) | 1987-04-22 | — | — | EP | disclosed |