Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | THRA | P10827 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | TACR2 | P21452 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10530872 | 0.92 | KCNH2 (0.71) | MAPTKCNH2HTR2ATHRATHRB | |
| SCHEMBL30010815 | 0.91 | MAPT (0.61) | MAPTKCNH2HTR2ATHRATHRB | |
| SCHEMBL7932030 | 0.91 | MAPT (0.70) | MAPTKCNH2HTR2ATHRATHRB | |
| SCHEMBL22346499 | 0.87 | HTR2A (0.76) | MAPTHTR2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL23754742 | 0.87 | HTR2A (0.76) | MAPTHTR2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL25171839 | 0.87 | HTR2A (0.76) | MAPTHTR2AKDM4EALDH1A1HSD17B10 | |
| Undecane SCHEMBL22346217 | 0.87 | HTR2A (0.76) | MAPTHTR2AKDM4EALDH1A1HSD17B10 | |
| Tridecane SCHEMBL22346186 | 0.87 | HTR2A (0.76) | MAPTHTR2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL22346225 | 0.87 | HTR2A (0.76) | MAPTHTR2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL22346501 | 0.87 | HTR2A (0.76) | MAPTHTR2AKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178874-B1 | ALKYLSULFONAMIDOPHENYLALKYLAMINES | ELI LILLY AND COMPANY (US) | 1989-04-05 | — | — | EP | disclosed |
| US-4596827-A | Antiarrhythmia agents | ELI LILLY AND COMPANY (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0178874-A1 | Alkylsulfonamidophenylalkylamines | ELI LILLY AND COMPANY (US) | 1986-04-23 | — | — | EP | disclosed |
| US-4569801-A | ANTIARRHYTHMIA AGENTS | ELI LILLY AND COMPANY (US) | 1986-02-11 | — | — | US | disclosed |