Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | SCN1A | P35498 | 1/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10529931 | 0.91 | MAPT (0.64) | MAPTKCNH2CHRM2SLC6A3HTR2A | |
| SCHEMBL12156482 | 0.86 | KCNH2 (0.60) | MAPTKCNH2CHRM2HTR1ADRD3 | |
| SCHEMBL22403770 | 0.86 | KCNH2 (0.66) | MAPTKCNH2CHRM2HTR1ADRD3 | |
| SCHEMBL30010815 | 0.85 | MAPT (0.61) | MAPTKCNH2DRD3HTR2ATHRA | |
| SCHEMBL111607 | 0.83 | GFER (0.62) | MAPTCHRM2SLC6A3HTR2ALMNA | |
| SCHEMBL23086272 | 0.82 | HTR2A (0.52) | MAPTHTR2ACYP1A2CYP3A4GAA | |
| SCHEMBL18347163 | 0.82 | MAPT (1.00) | MAPTKCNH2CHRM2HTR1ADRD3 | |
| SCHEMBL10530872 | 0.82 | KCNH2 (0.71) | MAPTKCNH2CHRM2HTR1ADRD3 | |
| SCHEMBL3123212 | 0.82 | MAPT (0.49) | MAPTBCHE | |
| SCHEMBL6475263 | 0.81 | MAPT (0.56) | MAPTHTR2ACYP3A4MAOBGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059711-A1 | SIGMA-1 RECEPTOR LIGANDS AND METHODS OF USE | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-05-27 | — | — | WO | disclosed |