Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.71 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624160 | 0.93 | KCNH2 (0.62) | KCNH2HTR2AMAPTADRA2ASLC6A2 | |
| SCHEMBL10529931 | 0.92 | MAPT (0.64) | KCNH2HTR2AMAPTADRA2ASLC6A2 | |
| SCHEMBL5632446 | 0.90 | KCNH2 (0.56) | KCNH2HTR2AMAPTADRA2ASLC6A2 | |
| SCHEMBL22403770 | 0.88 | KCNH2 (0.66) | KCNH2MAPTADRA2ASLC6A2SLC6A4 | |
| SCHEMBL30010815 | 0.86 | MAPT (0.61) | KCNH2HTR2AMAPTOPRM1DRD3 | |
| SCHEMBL23754742 | 0.86 | HTR2A (0.76) | HTR2AMAPTADRA2ASLC6A2SLC6A4 | |
| SCHEMBL22346250 | 0.86 | HTR2A (0.76) | HTR2AMAPTADRA2ASLC6A2SLC6A4 | |
| SCHEMBL22346499 | 0.86 | HTR2A (0.76) | HTR2AMAPTADRA2ASLC6A2SLC6A4 | |
| SCHEMBL25171839 | 0.86 | HTR2A (0.76) | HTR2AMAPTADRA2ASLC6A2SLC6A4 | |
| SCHEMBL22346194 | 0.86 | HTR2A (0.76) | HTR2AMAPTADRA2ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178874-B1 | ALKYLSULFONAMIDOPHENYLALKYLAMINES | ELI LILLY AND COMPANY (US) | 1989-04-05 | — | — | EP | disclosed |
| EP-0107452-B1 | IMPROVEMENTS IN OR RELATING TO IMAGING AGENTS | ELI LILLY AND COMPANY (US) | 1987-02-04 | — | — | EP | disclosed |
| US-4596827-A | Antiarrhythmia agents | ELI LILLY AND COMPANY (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0178874-A1 | Alkylsulfonamidophenylalkylamines | ELI LILLY AND COMPANY (US) | 1986-04-23 | — | — | EP | disclosed |
| US-4569801-A | ANTIARRHYTHMIA AGENTS | ELI LILLY AND COMPANY (US) | 1986-02-11 | — | — | US | disclosed |
| US-4528177-A | Imaging agents and method | ELI LILLY AND COMPANY (US) | 1985-07-09 | — | — | US | disclosed |
| EP-0107452-A1 | Improvements in or relating to imaging agents | ELI LILLY AND COMPANY (US) | 1984-05-02 | — | — | EP | disclosed |