Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.45 |
| ▸ | THRA | P10827 | 2/20 | 0.45 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.38 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029113 | 0.89 | THRA (0.45) | CYP19A1THRBTHRACYP27A1CYP24A1 | |
| SCHEMBL10534814 | 0.86 | THRA (0.40) | CYP19A1THRBTHRACYP27A1CYP24A1 | |
| SCHEMBL10536475 | 0.86 | CYP19A1 (0.60) | CYP19A1THRBTHRAMAOBMAOA | |
| SCHEMBL10536446 | 0.85 | CYP19A1 (0.48) | CYP19A1THRBTHRAMAOBMAOA | |
| SCHEMBL10534293 | 0.83 | CYP19A1 (0.47) | CYP19A1THRBTHRACYP24A1MAOB | |
| SCHEMBL8030854 | 0.83 | GPBAR1 (0.55) | SMN1; SMN2HPGDALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL9341455 | 0.82 | GPBAR1 (0.54) | SMN1; SMN2HPGDALDH1A1LMNA | |
| SCHEMBL10534736 | 0.81 | NPC1 (0.47) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8028175 | 0.81 | CYP19A1 (0.61) | CYP19A1THRBTHRACYP27A1CYP24A1 | |
| SCHEMBL10533568 | 0.80 | GPBAR1 (0.53) | THRBTHRASMN1; SMN2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989003681-A1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |