Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10534693 | 0.81 | CYP19A1 (0.47) | MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8030854 | 0.81 | GPBAR1 (0.55) | SMN1; SMN2MAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL10534814 | 0.81 | THRA (0.40) | SMN1; SMN2ALOX5PDE10A | |
| Hydrochloric Acid SCHEMBL9341455 | 0.81 | GPBAR1 (0.54) | SMN1; SMN2MAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL8029113 | 0.79 | THRA (0.45) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL10533568 | 0.78 | GPBAR1 (0.53) | SMN1; SMN2MAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL10536475 | 0.77 | CYP19A1 (0.60) | — | |
| SCHEMBL10536446 | 0.76 | CYP19A1 (0.48) | — | |
| SCHEMBL8028175 | 0.74 | CYP19A1 (0.61) | — | |
| SCHEMBL10534293 | 0.74 | CYP19A1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989003681-A1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |