Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 16/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10539066 | 0.85 | CA2 (0.42) | CYP26A1CA2CYP19A1CA1 | |
| SCHEMBL10538434 | 0.78 | CA2 (0.58) | CYP26A1CA2 | |
| SCHEMBL10537856 | 0.63 | CA2 (0.44) | CA2CA1 | |
| SCHEMBL9463920 | 0.62 | CA2 (0.63) | CA2 | |
| SCHEMBL10561142 | 0.61 | CYP26A1 (0.43) | CYP26A1CA2CYP19A1CA1 | |
| SCHEMBL10542143 | 0.61 | CA2 (0.46) | CA2CYP19A1 | |
| SCHEMBL10373236 | 0.59 | CA2 (0.56) | CA2CA1 | |
| SCHEMBL14734507 | 0.59 | GRIN2B (0.49) | — | |
| SCHEMBL16902819 | 0.59 | GRIN2B (0.49) | — | |
| SCHEMBL10512250 | 0.58 | CA2 (0.57) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863922-A | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use | MERCK & CO., INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4824968-A | REMOVING HYDROXYL GROUP WITH SODIUM IODIDE AND DICHLORODIMETHYLSILANE IN ACETONITRILE | MERCK & CO., INC. (US) | 1989-04-25 | — | — | US | disclosed |
| US-4820848-A | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO., INC. (US) | 1989-04-11 | — | — | US | disclosed |
| US-4797413-A | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use | MERCK & CO., INC. (US) | 1989-01-10 | — | — | US | disclosed |
| EP-0296879-A1 | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-28 | — | — | EP | disclosed |