Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10539494 | 0.82 | SIRT2 (0.32) | ENPP2 | |
| SCHEMBL9521500 | 0.78 | TSHR (0.41) | TSHRUSP2ALDH1A1KMT2ANPC1 | |
| SCHEMBL9521480 | 0.77 | TSHR (0.40) | TSHRUSP2ALDH1A1KMT2ANPC1 | |
| SCHEMBL31298404 | 0.74 | PARP1 (0.47) | NPSR1MAPTENPP2HCRTR1HCRTR2 | |
| SCHEMBL5682164 | 0.73 | CYP11B1 (0.43) | KMT2AENPP2CYP1A2 | |
| SCHEMBL3752469 | 0.72 | HCRTR1 (0.40) | USP2KMT2AMEN1MAPTENPP2 | |
| SCHEMBL23879944 | 0.69 | ALDH1A1 (0.43) | TSHRUSP2ALDH1A1KMT2ANPC1 | |
| SCHEMBL693097 | 0.69 | CYP11B1 (0.41) | TSHRUSP2KMT2ARAB9AMEN1 | |
| SCHEMBL670904 | 0.68 | CYP11B1 (0.43) | TSHRALDH1A1HPGDENPP2KDM4E | |
| SCHEMBL9518291 | 0.68 | TSHR (0.35) | TSHRUSP2ALDH1A1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4816452-A | ANTIBIOTICS | BEECHAM GROUP P.L.C. (GB) | 1989-03-28 | — | — | US | disclosed |
| US-4814343-A | ANTIISCHEMIC | U C B, S.A. (BE) | 1989-03-21 | — | — | US | disclosed |
| EP-0210815-A2 | 6-Beta-(alpha-etherified oxyimino)-acylamino penicillanic-acid derivatives, their preparation and use | BEECHAM GROUP PLC (GB) | 1987-02-04 | — | — | EP | disclosed |