Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | BLM | P54132 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.45 |
| ▸ | DRD1 | P21728 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12977811 | 0.82 | SIGMAR1 (0.58) | SIGMAR1KCNH2MAPTBLMMEN1 | |
| SCHEMBL10539847 | 0.81 | SIGMAR1 (0.51) | SIGMAR1MEN1KMT2ALMNAABCB1 | |
| SCHEMBL7985198 | 0.77 | MAPT (0.50) | MAPTBLMMEN1KMT2AADRA1D | |
| SCHEMBL10538216 | 0.75 | SIGMAR1 (0.61) | SIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL10537108 | 0.72 | KMT2A (0.68) | KCNH2MEN1KMT2AADRA1DADRA1A | |
| SCHEMBL11377612 | 0.71 | ADRA1D (0.48) | SIGMAR1KCNH2MAPTBLMMEN1 | |
| SCHEMBL13913717 | 0.70 | KCNH2 (0.51) | SIGMAR1KCNH2MAPTBLMMEN1 | |
| SCHEMBL8847942 | 0.70 | MAPT (0.56) | MAPTBLMMEN1KMT2AADRA1D | |
| SCHEMBL8848145 | 0.69 | TDP1 (0.60) | MAPTBLMMEN1KMT2AADRA1D | |
| SCHEMBL10537607 | 0.69 | KMT2A (0.62) | SIGMAR1KCNH2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0346367-A1 | ARYL- AND ARYLOXY-SUBSTITUTED TERT.-ALKYLENAMINES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE IN PHARMACY | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-12-20 | — | — | EP | disclosed |
| WO-1988006580-A1 | ARYL- AND ARYLOXY-SUBSTITUTED TERT.-ALKYLENAMINES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE IN PHARMACY | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-09-07 | — | — | WO | disclosed |