Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.34 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10547140 | 0.78 | CYP19A1 (0.39) | SLC6A2SLC6A4SLC6A3GAACYP3A4 | |
| SCHEMBL11107347 | 0.75 | HTT (0.39) | SLC6A2SLC6A4SLC6A3KMT2AATM | |
| SCHEMBL9783044 | 0.70 | LMNA (0.34) | GAAKMT2ALMNASMN1; SMN2HSD17B10 | |
| SCHEMBL8963677 | 0.70 | MEN1 (0.45) | SLC6A2SLC6A4SLC6A3KMT2ACYP3A4 | |
| SCHEMBL10739427 | 0.68 | ABCB1 (0.37) | SLC6A2SLC6A4SLC6A3KMT2AGABRR1 | |
| SCHEMBL11336370 | 0.67 | GABRR1 (0.47) | LMNASMN1; SMN2GABRR1HTR3AKDM4E | |
| SCHEMBL2626802 | 0.65 | ADRA2A (0.54) | SLC6A2ATMCYP3A4CYP19A1 | |
| SCHEMBL2105250 | 0.64 | LMNA (0.38) | GAAKMT2ALMNASMN1; SMN2HSD17B10 | |
| SCHEMBL12342223 | 0.64 | HRH2 (0.38) | SMN1; SMN2GABRR1CDK1CCNB1CCNA2 | |
| SCHEMBL27933518 | 0.63 | GAA (0.45) | SLC6A2SLC6A4SLC6A3GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4826864-A | Substituted imidazole derivatives useful as antihypertensive or antithromtic agent or divretic | FARMOS GROUP LTD. (FI) | 1989-05-02 | — | — | US | disclosed |
| US-4639464-A | Antihypertensive substituted imidazole derivatives | FARMOS GROUP, LTD. (FI) | 1987-01-27 | — | — | US | disclosed |
| EP-0072615-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos Group Ltd. (FI) | 1985-12-27 | — | — | EP | disclosed |
| US-4544664-A | Antihypertensive substituted imidazole derivatives | FARMOS GROUP, LTD. (FI) | 1985-10-01 | — | — | US | disclosed |
| EP-0072615-A1 | Substituted imidazole derivatives and their preparation and use | Farmos Group Ltd. (FI) | 1983-02-23 | — | — | EP | disclosed |