Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7322278 | 0.99 | KDM4E (0.43) | KDM4EESR1ESR2HSD17B1HSD17B2 | |
| Hydrochloric Acid SCHEMBL7325666 | 0.84 | KDM4E (0.42) | KDM4ECYP1A2CYP2C19MEN1LMNA | |
| Hydrochloric Acid SCHEMBL7318919 | 0.82 | S1PR1 (0.47) | KDM4ECYP1A2CYP2C19LMNARXRA | |
| SCHEMBL7318500 | 0.80 | KDM4E (0.42) | KDM4ECYP1A2CYP2C19MEN1LMNA | |
| Hydrochloric Acid SCHEMBL7323883 | 0.79 | KDM4E (0.41) | KDM4ECYP1A2CYP2C19MEN1LMNA | |
| SCHEMBL399205 | 0.77 | ALDH1A1 (0.46) | KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL7329113 | 0.76 | CYP1A2 (0.57) | KDM4ECYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL10550294 | 0.76 | KDM4E (0.41) | KDM4EESR1ESR2HSD17B1HSD17B2 | |
| Hydrochloric Acid SCHEMBL7320004 | 0.75 | CYP1A2 (0.39) | KDM4ECYP1A2CYP2C19MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7322286 | 0.75 | KDM4E (0.40) | KDM4EESR1ESR2HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882354-A | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1989-11-21 | — | — | US | disclosed |