Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10554610 | 0.86 | KDM4E (0.39) | LMNAKDM4EALDH1A1POLBRXFP1 | |
| SCHEMBL10554793 | 0.84 | RXRA (0.43) | KDM4EALDH1A1HPGDNOTUMADORA2A | |
| SCHEMBL10553556 | 0.82 | KDM4E (0.40) | LMNAKDM4EALDH1A1POLBRXFP1 | |
| SCHEMBL10555308 | 0.80 | CHUK (0.36) | CYP11B2KDM4ERXFP1HPGDADORA2A | |
| SCHEMBL10554560 | 0.78 | CYP11B2 (0.39) | CYP11B2LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL9468466 | 0.77 | KDM4E (0.50) | KDM4EALDH1A1HPGDHRH1 | |
| SCHEMBL10552707 | 0.77 | LRRK2 (0.43) | HTTKDM4EALDH1A1RXFP1HPGD | |
| SCHEMBL10553054 | 0.77 | LRRK2 (0.38) | — | |
| SCHEMBL9468321 | 0.73 | CSNK2A1 (0.46) | HTTKDM4EALDH1A1RXFP1HPGD | |
| SCHEMBL9468407 | 0.72 | KDM4E (0.42) | KDM4ERXRARXRBRXRGEGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847256-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0264773-A1 | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |