Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | POLB | P06746 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | GLA | P06280 | 5/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10555484 | 0.87 | LMNA (0.51) | ALDH1A1MAPTSMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL10553046 | 0.87 | LMNA (0.51) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10553294 | 0.86 | LMNA (0.52) | ALDH1A1MAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL10553321 | 0.85 | LMNA (0.52) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10550172 | 0.83 | NPC1 (0.60) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10551608 | 0.82 | LMNA (0.49) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10553748 | 0.81 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10556108 | 0.81 | LMNA (0.49) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10554631 | 0.80 | LMNA (0.49) | ALDH1A1MAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL10551194 | 0.80 | LMNA (0.48) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831032-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE, ISOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-16 | — | — | US | disclosed |
| EP-0207483-A2 | Benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1987-01-07 | — | — | EP | disclosed |