Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 5/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28009196 | 0.80 | NISCH (0.46) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL9271844 | 0.79 | MTOR (0.42) | ALDH1A1HPGDGAAMAPTMEN1 | |
| SCHEMBL26464181 | 0.78 | MAPT (0.50) | ALOX12ALDH1A1HPGDPKMGAA | |
| SCHEMBL17707841 | 0.78 | ALDH1A1 (0.48) | ALOX12ALDH1A1HPGDPKMGAA | |
| SCHEMBL19052768 | 0.76 | NPC1 (0.51) | ALDH1A1MEN1KMT2AHSD17B10NPC1 | |
| SCHEMBL10554989 | 0.76 | GAA (0.44) | ALOX12ALDH1A1HPGDPKMGAA | |
| SCHEMBL10558941 | 0.76 | ALDH1A1 (0.44) | ALOX12ALDH1A1HPGDPKMGAA | |
| SCHEMBL10558227 | 0.74 | ALDH1A1 (0.43) | ALOX12ALDH1A1HPGDPKMGAA | |
| SCHEMBL25792011 | 0.73 | KDM4E (0.57) | ALDH1A1HPGDPKMGAAMAPT | |
| SCHEMBL27346201 | 0.72 | KDM4E (0.53) | ALOX12ALDH1A1HPGDGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853383-A | β-blocking substituted imidazoles | MERCK & CO., INC. (US) | 1989-08-01 | — | — | US | disclosed |
| US-4642311-A | β-adrenergic blocking imidazolylphenoxy propanolamines | MERCK & CO., INC. (US) | 1987-02-10 | — | — | US | disclosed |