Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10554521 | 1.00 | POLB (0.61) | POLBHRH3HTR1ADRD2HTR2A | |
| SCHEMBL10556415 | 0.99 | POLB (0.62) | POLBHRH3HTR1ADRD2HTR2A | |
| SCHEMBL10553527 | 0.84 | POLB (0.53) | POLBHTR1ADRD2HTR2AALDH1A1 | |
| SCHEMBL10551296 | 0.83 | ALDH1A1 (0.55) | POLBHTR1ADRD2HTR2AALDH1A1 | |
| SCHEMBL10556424 | 0.82 | POLB (0.53) | POLBHTR1ADRD2HTR2AALDH1A1 | |
| SCHEMBL18159251 | 0.82 | HRH3 (0.55) | HRH3HTR1ADRD2HTR2ASIGMAR1 | |
| SCHEMBL10553555 | 0.80 | HRH3 (0.61) | HRH3SIGMAR1MEN1KMT2ASLC6A3 | |
| SCHEMBL10555657 | 0.80 | HRH3 (0.61) | HRH3SIGMAR1MEN1KMT2ASLC6A3 | |
| SCHEMBL10553541 | 0.80 | POLB (0.50) | POLBALDH1A1MEN1KMT2ACTSV | |
| SCHEMBL6814063 | 0.79 | POLB (0.54) | POLBHTR1AALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847269-A | GLAUCOMA, AMIDES OR UREA DERIVATIVES OF AMINOETHYLCARBOXY COMPOUNDS | SYNTEX (U.S.A.) INC. (US) | 1989-07-11 | — | — | US | disclosed |
| US-4629730-A | ADMINISTERING DIALKYL OR CYCLOAKYL AMINO ETHYLANILINE DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1986-12-16 | — | — | US | disclosed |
| EP-0180994-A2 | Antihypertensive dialkyl aminoethylaniline derivatives | SYNTEX (U.S.A.) INC. (US) | 1986-05-14 | — | — | EP | disclosed |