Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 3/20 | 0.49 |
| ▸ | EBP | Q15125 | 2/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10553555 | 1.00 | HRH3 (0.61) | HRH3SIGMAR1SLC6A3MEN1KMT2A | |
| SCHEMBL10556006 | 0.99 | HRH3 (0.63) | HRH3SIGMAR1SLC6A3MEN1KMT2A | |
| SCHEMBL10560091 | 0.82 | HRH3 (0.43) | HRH3SIGMAR1EBPTMEM97 | |
| SCHEMBL10556225 | 0.81 | HRH3 (0.41) | HRH3SIGMAR1MEN1KMT2AEBP | |
| SCHEMBL10923941 | 0.80 | SIGMAR1 (0.54) | HRH3SIGMAR1MEN1KMT2A | |
| SCHEMBL10922973 | 0.80 | SIGMAR1 (0.54) | HRH3SIGMAR1MEN1KMT2A | |
| SCHEMBL10556018 | 0.80 | HMOX1 (0.44) | HRH3LTA4HAPP | |
| SCHEMBL10554521 | 0.80 | POLB (0.61) | HRH3SIGMAR1SLC6A3MEN1KMT2A | |
| SCHEMBL10554135 | 0.80 | POLB (0.61) | HRH3SIGMAR1SLC6A3MEN1KMT2A | |
| SCHEMBL18159245 | 0.80 | SIGMAR1 (0.57) | HRH3SIGMAR1EBPTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847269-A | GLAUCOMA, AMIDES OR UREA DERIVATIVES OF AMINOETHYLCARBOXY COMPOUNDS | SYNTEX (U.S.A.) INC. (US) | 1989-07-11 | — | — | US | disclosed |
| US-4629730-A | ADMINISTERING DIALKYL OR CYCLOAKYL AMINO ETHYLANILINE DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1986-12-16 | — | — | US | disclosed |
| EP-0180994-A2 | Antihypertensive dialkyl aminoethylaniline derivatives | SYNTEX (U.S.A.) INC. (US) | 1986-05-14 | — | — | EP | disclosed |