Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | OGA | O60502 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10551212 | 0.78 | ALDH1A1 (0.39) | CYP2D6TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3745991 | 0.76 | TAAR1 (0.47) | CYP2D6CYP1A2CYP3A4TAAR1SLC6A2 | |
| SCHEMBL10551331 | 0.72 | MAOA (0.44) | TAAR1 | |
| SCHEMBL2618697 | 0.72 | CYP2D6 (0.53) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22702810 | 0.71 | MEN1 (0.40) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11621846 | 0.70 | TAAR1 (0.51) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3753050 | 0.70 | PTGS1 (0.47) | — | |
| SCHEMBL18898369 | 0.69 | EDNRA (0.40) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22854153 | 0.69 | MEN1 (0.52) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL24199763 | 0.69 | CYP1A2 (0.40) | CYP2D6CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4639464-A | Antihypertensive substituted imidazole derivatives | FARMOS GROUP, LTD. (FI) | 1987-01-27 | — | — | US | claimed |
| EP-0072615-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos Group Ltd. (FI) | 1985-12-27 | — | — | EP | claimed |
| EP-0072615-A1 | Substituted imidazole derivatives and their preparation and use | Farmos Group Ltd. (FI) | 1983-02-23 | — | — | EP | claimed |
| US-4826864-A | Substituted imidazole derivatives useful as antihypertensive or antithromtic agent or divretic | FARMOS GROUP LTD. (FI) | 1989-05-02 | — | — | US | disclosed |
| US-4639464-A | Antihypertensive substituted imidazole derivatives | FARMOS GROUP, LTD. (FI) | 1987-01-27 | — | — | US | disclosed |
| EP-0072615-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos Group Ltd. (FI) | 1985-12-27 | — | — | EP | disclosed |
| US-4544664-A | Antihypertensive substituted imidazole derivatives | FARMOS GROUP, LTD. (FI) | 1985-10-01 | — | — | US | disclosed |
| EP-0072615-A1 | Substituted imidazole derivatives and their preparation and use | Farmos Group Ltd. (FI) | 1983-02-23 | — | — | EP | disclosed |