Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10553207 | 1.00 | HRH3 (0.54) | HRH3SIGMAR1MEN1KMT2ASLC6A3 | |
| SCHEMBL10555526 | 0.99 | HRH3 (0.55) | HRH3SIGMAR1MEN1KMT2ASLC6A3 | |
| SCHEMBL10557212 | 0.85 | HTR6 (0.40) | HRH3SIGMAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL10923941 | 0.83 | SIGMAR1 (0.54) | HRH3SIGMAR1MEN1KMT2AMET | |
| SCHEMBL10922973 | 0.83 | SIGMAR1 (0.54) | HRH3SIGMAR1MEN1KMT2AMET | |
| SCHEMBL10551022 | 0.83 | KDM4E (0.39) | HRH3SIGMAR1MEN1KMT2AKDM4E | |
| SCHEMBL10555532 | 0.83 | FFAR4 (0.40) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10554118 | 0.83 | BRD4 (0.56) | HRH3SIGMAR1MEN1KMT2AMET | |
| Bromide SCHEMBL10552937 | 0.83 | SIGMAR1 (0.53) | HRH3SIGMAR1MEN1KMT2AMET | |
| SCHEMBL10554709 | 0.83 | BRD4 (0.56) | HRH3SIGMAR1MEN1KMT2AMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847269-A | GLAUCOMA, AMIDES OR UREA DERIVATIVES OF AMINOETHYLCARBOXY COMPOUNDS | SYNTEX (U.S.A.) INC. (US) | 1989-07-11 | — | — | US | disclosed |
| US-4629730-A | ADMINISTERING DIALKYL OR CYCLOAKYL AMINO ETHYLANILINE DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1986-12-16 | — | — | US | disclosed |
| EP-0180994-A2 | Antihypertensive dialkyl aminoethylaniline derivatives | SYNTEX (U.S.A.) INC. (US) | 1986-05-14 | — | — | EP | disclosed |