Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10556727 | 0.78 | TLR8 (0.40) | RAB9ANPC1KMT2AKDM4CKDM5A | |
| SCHEMBL15168370 | 0.67 | RAB9A (0.64) | NR4A3SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL3172208 | 0.65 | MAPK13 (0.70) | SMN1; SMN2RAB9AHPGDALDH1A1MAPK13 | |
| SCHEMBL13730873 | 0.63 | CASR (0.55) | SMN1; SMN2HPGDTP53MAPTGAA | |
| SCHEMBL13730875 | 0.63 | CASR (0.55) | SMN1; SMN2HPGDTP53MAPTGAA | |
| SCHEMBL15168145 | 0.62 | RAB9A (0.48) | NR4A3SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL31547085 | 0.60 | SMN1; SMN2 (0.47) | NR4A3SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL27189130 | 0.59 | NR4A3 (0.78) | NR4A3SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL20594609 | 0.58 | RAB9A (0.54) | SMN1; SMN2RAB9ACA12ALPLCA9 | |
| SCHEMBL202160 | 0.58 | LTB4R2 (0.61) | SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847256-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0264773-A1 | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |