Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13730877 | 1.00 | CASR (0.55) | CASRALDH1A1KDM4EATMGAA | |
| SCHEMBL13730873 | 1.00 | CASR (0.55) | CASRALDH1A1KDM4EATMGAA | |
| SCHEMBL3986106 | 0.87 | CASR (0.69) | CASRALDH1A1KDM4EATMGAA | |
| SCHEMBL13731638 | 0.86 | ALDH1A1 (0.62) | CASRALDH1A1KDM4EATMGAA | |
| SCHEMBL13730563 | 0.86 | ALDH1A1 (0.52) | CASRALDH1A1KDM4EATMGAA | |
| SCHEMBL13731640 | 0.86 | ALDH1A1 (0.62) | CASRALDH1A1KDM4EATMGAA | |
| SCHEMBL13731644 | 0.86 | ALDH1A1 (0.62) | CASRALDH1A1KDM4EATMGAA | |
| SCHEMBL13730561 | 0.86 | ALDH1A1 (0.52) | CASRALDH1A1KDM4EATMGAA | |
| SCHEMBL13730566 | 0.86 | ALDH1A1 (0.52) | CASRALDH1A1KDM4EATMGAA | |
| SCHEMBL13730348 | 0.85 | ALDH1A1 (0.53) | CASRALDH1A1KDM4EATMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699577-A1 | TETRAHYDROPYRAZOLO [1,5 -A]PYRIMIDINE AS ANTI -TUBERCULOSIS COMPOUNDS | Glaxo Group Limited (GB) | 2014-02-26 | — | — | EP | disclosed |
| US-20140038989-A1 | TETRAHYDROPYRAZOLO [1,5-A] PYRIMIDINE AS ANTI-TUBERCULOSIS COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2014-02-06 | — | — | US | disclosed |
| WO-2012143522-A1 | TETRAHYDROPYRAZOLO [1,5 -A] PYRIMIDINE AS ANTI -TUBERCULOSIS COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038989-A1 | TETRAHYDROPYRAZOLO [1,5-A] PYRIMIDINE AS ANTI-TUBERCULOSIS COMPOUNDS | TBL3, NDUFV3, NME2 | CASR 4528/4885ALDH1A1 1939/4885KDM4E 1762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.