Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.34 |
| ▸ | PDE2A | O00408 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | MAT2A | P31153 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10553294 | 0.73 | LMNA (0.52) | LMNAPDE3BPDE3AMAPT | |
| SCHEMBL10556108 | 0.73 | LMNA (0.49) | LMNAPDE3BPDE3APDE2AKMT2A | |
| SCHEMBL10554184 | 0.73 | LMNA (0.46) | LMNAPDE3BPDE3APDE2AKMT2A | |
| SCHEMBL9677526 | 0.73 | LMNA (0.54) | LMNAPDE3BPDE3APDE2AKMT2A | |
| SCHEMBL10551194 | 0.72 | LMNA (0.48) | LMNAPDE3BPDE3APDE2AKMT2A | |
| SCHEMBL10555484 | 0.72 | LMNA (0.51) | LMNAMAPT | |
| SCHEMBL10552014 | 0.72 | MEN1 (0.55) | LMNAKMT2AMAPTTP53MEN1 | |
| SCHEMBL10553112 | 0.72 | LMNA (0.44) | LMNAPDE3BPDE3APDE2AKMT2A | |
| SCHEMBL10553046 | 0.72 | LMNA (0.51) | LMNAKMT2AMAPTTP53PGR | |
| SCHEMBL10552596 | 0.72 | LMNA (0.48) | LMNAPDE3BPDE3APDE2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831032-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE, ISOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-16 | — | — | US | disclosed |
| EP-0207483-A2 | Benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1987-01-07 | — | — | EP | disclosed |