Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 17/20 | 0.80 |
| ▸ | HRH1 | P35367 | 17/20 | 0.80 |
| ▸ | ADRA1B | P35368 | 17/20 | 0.80 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.74 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.74 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.74 |
| ▸ | HTR2A | P28223 | 2/20 | 0.74 |
| ▸ | DRD3 | P35462 | 2/20 | 0.74 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.74 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.74 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.74 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.74 |
| ▸ | HTR2C | P28335 | 1/20 | 0.74 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.74 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2615137 | 0.96 | HRH1 (0.81) | ADRA1AHRH1ADRA1BHRH3ADRA2A | |
| SCHEMBL2615138 | 0.96 | HRH1 (0.81) | ADRA1AHRH1ADRA1BHRH3ADRA2A | |
| SCHEMBL10762965 | 0.85 | ABCB1 (0.73) | ADRA1AHRH1ADRA1BHRH3ADRA2A | |
| Azelastine SCHEMBL4239 | 0.85 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3ADRA2A | |
| Azelastine SCHEMBL30910968 | 0.85 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3ADRA2A | |
| Azelastine SCHEMBL29370712 | 0.85 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3ADRA2A | |
| Azelastine SCHEMBL4433245 | 0.85 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3ADRA2A | |
| Azelastine SCHEMBL17223862 | 0.85 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3ADRA2A | |
| Azelastine SCHEMBL4240 | 0.85 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3ADRA2A | |
| Azelastine SCHEMBL17803891 | 0.85 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4841047-A | ANTIALLERGENS | AASTA PHARMA AG (DE) | 1989-06-20 | — | — | US | disclosed |
| EP-0222191-A1 | 4-Benzyl-1-2(H)-phthalazinone derivatives | ASTA Pharma AG (DE) | 1987-05-20 | — | — | EP | disclosed |