Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azelastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 17/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 17/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 17/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 6/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azelastine SCHEMBL17803891 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL17223862 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL30910968 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL29370712 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL4239 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL4433245 | 1.00 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL36770 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL19458799 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL4012083 | 0.99 | ADRA1A (0.98) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL36771 | 0.99 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 18736 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436924-B1 | — | — | None | — | — | US | claimed |
| US-20260139860-A1 | PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2026-05-21 | — | — | US | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| EP-4731194-A1 | MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT | CSP Technologies, Inc. (US) | 2026-04-29 | — | — | EP | claimed |
| EP-4724079-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION | Stealth BioTherapeutics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| EP-4704971-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| WO-2026042047-A1 | COMPOSITIONS AND ARTICLES COMPRISING REVERSIBLE COMPLEXES OF CROSSLINKED CARRAGEENAN | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2026-02-26 | — | — | WO | claimed |
| US-5019591-A | Antihistamines | PENNSYLVANIA RESEARCH CORPORATION (US) | 1991-05-28 | — | — | US | claimed |
| EP-0402422-A1 | CERTAIN PAF ANTAGONIST ANTIHISTAMINE COMBINATIONS AND METHODS | SCHERING CORPORATION (US) | 1990-12-19 | — | — | EP | claimed |
| EP-0345931-A1 | Certain PAF antagonist/antihistamine combinations and methods | SCHERING CORPORATION (US) | 1989-12-13 | — | — | EP | claimed |
| WO-1989010143-A1 | CERTAIN PAF ANTAGONIST ANTIHISTAMINE COMBINATIONS AND METHODS | SCHERING CORPORATION (US) | 1989-11-02 | — | — | WO | claimed |
| EP-0316434-A4 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS. | SUNSHINE ABRAHAM (US) | 1989-10-16 | — | — | EP | claimed |
| US-4871733-A | WITH NON-STEROIDAL ANTIINFLAMMATORY | ANALGESIC ASSOCIATES (US) | 1989-10-03 | — | — | US | claimed |
| EP-0316434-A1 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS. | SUNSHINE ABRAHAM (US) | 1989-05-24 | — | — | EP | claimed |
| EP-0311677-A1 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS. | SUNSHINE ABRAHAM (US) | 1989-04-19 | — | — | EP | claimed |
| WO-1988009656-A1 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS | SUNSHINE ABRAHAM (US) | 1988-12-15 | — | — | WO | claimed |
| WO-1988008302-A1 | COUGH/COLD MIXTURES COMPRISING NON-SEDATING ANTIHISTAMINE DRUGS | SUNSHINE ABRAHAM (US) | 1988-11-03 | — | — | WO | claimed |