Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 12/20 | 0.50 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764905 | 0.85 | ALOX5 (0.56) | ALOX5BCHEACHE | |
| SCHEMBL9764900 | 0.84 | ALOX5 (0.55) | ALOX5BCHEACHE | |
| SCHEMBL10608085 | 0.84 | ALOX5 (0.55) | ALOX5BCHEACHE | |
| SCHEMBL10561140 | 0.82 | ALOX5 (0.53) | ALOX5 | |
| SCHEMBL9764877 | 0.78 | ALOX5 (0.56) | ALOX5 | |
| Tetrabuthylammonium SCHEMBL9764880 | 0.77 | NPC1 (0.44) | ALOX5BCHEACHE | |
| SCHEMBL9764809 | 0.76 | PLA2G10 (0.40) | ALOX5ECE1 | |
| SCHEMBL9764910 | 0.75 | BCHE (0.52) | BCHEACHE | |
| SCHEMBL9764862 | 0.75 | BCHE (0.49) | ALOX5BCHEACHEECE1 | |
| SCHEMBL9473741 | 0.75 | ALOX5 (0.73) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0346939-A1 | Tricyclic lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4822811-A | Carbazole lipoxygenase inhibiting compounds, compositions and use | ABBOTT LABORATORIES (US) | 1989-04-18 | — | — | US | disclosed |
| US-4769387-A | Dibenzofuran lipoxygenase inhibiting compounds, compositions and use | ABBOTT LABORATORIES (US) | 1988-09-06 | — | — | US | disclosed |