Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.44 |
| ▸ | BCHE | P06276 | 4/20 | 0.42 |
| ▸ | ACHE | P22303 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764905 | 0.88 | ALOX5 (0.56) | NPC1RAB9ASMN1; SMN2ALOX5BCHE | |
| SCHEMBL10608085 | 0.86 | ALOX5 (0.55) | NPC1RAB9ASMN1; SMN2ALOX5BCHE | |
| SCHEMBL9764910 | 0.78 | BCHE (0.52) | NPC1RAB9ASMN1; SMN2BCHEACHE | |
| Ammonia Solution, Strong SCHEMBL9764871 | 0.77 | BCHE (0.51) | NPC1RAB9ASMN1; SMN2BCHEACHE | |
| SCHEMBL10560306 | 0.75 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2BCHEACHE | |
| SCHEMBL9764862 | 0.75 | BCHE (0.49) | NPC1RAB9ASMN1; SMN2ALOX5BCHE | |
| SCHEMBL10593822 | 0.74 | BCHE (0.44) | NPC1RAB9ASMN1; SMN2BCHEACHE | |
| SCHEMBL9764902 | 0.74 | BCHE (0.48) | NPC1RAB9ASMN1; SMN2ALOX5BCHE | |
| SCHEMBL10563244 | 0.73 | ALOX5 (0.45) | ALOX5BCHEACHE | |
| Tetrabuthylammonium SCHEMBL8807283 | 0.72 | ALOX5 (0.72) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0346939-A1 | Tricyclic lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4822811-A | Carbazole lipoxygenase inhibiting compounds, compositions and use | ABBOTT LABORATORIES (US) | 1989-04-18 | — | — | US | disclosed |
| US-4769387-A | Dibenzofuran lipoxygenase inhibiting compounds, compositions and use | ABBOTT LABORATORIES (US) | 1988-09-06 | — | — | US | disclosed |