SCHEMBL10559014

SCHEMBL10559014

O=S(=O)(c1cccc(C(F)(F)F)c1)N(Cc1cccnc1)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.55
MEN1 O00255 2/20 0.55
MAPT P10636 1/20 0.48
TRPM8 Q7Z2W7 3/20 0.48
GRM2 Q14416 6/20 0.46
SERPINE1 P05121 1/20 0.46
MMP1 P03956 1/20 0.46
MMP9 P14780 1/20 0.46
MMP13 P45452 1/20 0.46
ADAM17 P78536 1/20 0.46
TSHR P16473 1/20 0.45
CYP11B1 P15538 1/20 0.45
NAMPT P43490 2/20 0.44
HTR2C P28335 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10564152 0.82 GRM2 (0.48) KMT2AMEN1GRM2MMP1MMP9
Hydrochloric Acid SCHEMBL27672760 0.81 GRM2 (0.48) KMT2AMEN1GRM2MMP1MMP9
SCHEMBL10560010 0.76 GRM2 (0.57) GRM2
SCHEMBL6734090 0.74 GRM2 (0.66) GRM2
SCHEMBL6733966 0.70 GRM2 (0.60) GRM2MMP1MMP9MMP13ADAM17
SCHEMBL6731900 0.70 GRM2 (0.57) GRM2MMP1MMP9MMP13ADAM17
SCHEMBL10561032 0.70 TRPM8 (0.41) TRPM8GRM2MMP1MMP9MMP13
SCHEMBL6727585 0.69 GRM2 (0.74) GRM2
SCHEMBL6731051 0.69 GRM2 (0.67) GRM2
SCHEMBL6738615 0.69 GRM2 (0.65) GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4874775-A INHIBIT PHYTOPATHOGENS ELI LILLY AND COMPANY (US) 1989-10-17 US disclosed
EP-0206581-A2 Agriculturally-useful sulfonamides ELI LILLY AND COMPANY (US) 1986-12-30 EP disclosed