Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.55 |
| ▸ | CTSL | P07711 | 5/20 | 0.52 |
| ▸ | CTSB | P07858 | 5/20 | 0.52 |
| ▸ | CTSS | P25774 | 3/20 | 0.52 |
| ▸ | REN | P00797 | 1/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.50 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3029758 | 0.85 | CTSK (0.55) | CTSKCTSLCTSBCTSSREN | |
| SCHEMBL7293600 | 0.85 | REN (0.58) | CTSKCTSLCTSBCTSSREN | |
| SCHEMBL10420156 | 0.85 | REN (0.58) | CTSKCTSLCTSBCTSSREN | |
| SCHEMBL6502695 | 0.85 | CTSK (0.57) | CTSKCTSLCTSBCTSSREN | |
| SCHEMBL3042936 | 0.85 | CTSK (0.57) | CTSKCTSLCTSBCTSSREN | |
| SCHEMBL29865843 | 0.85 | CTSK (0.57) | CTSKCTSLCTSBCTSSREN | |
| SCHEMBL3042938 | 0.85 | CTSK (0.57) | CTSKCTSLCTSBCTSSREN | |
| SCHEMBL9970646 | 0.84 | ATM (0.54) | CTSKCTSLCTSBCTSS | |
| SCHEMBL8353955 | 0.84 | CTSK (0.62) | CTSKCTSLCTSBCTSSPSMB1 | |
| SCHEMBL10570700 | 0.84 | CTSK (0.54) | CTSKCTSLCTSBCTSSREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863903-A | RENIN ENZYME INHIBITORS, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |
| US-4719288-A | HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1988-01-12 | — | — | US | disclosed |
| US-4613676-A | PEPTIDES | CIBA-GEIGY CORPORATION (US) | 1986-09-23 | — | — | US | disclosed |
| EP-0143746-A2 | 5-Amino 4-hydroxy-valeryl-substituted derivatives | CIBA-GEIGY AG (CH) | 1985-06-05 | — | — | EP | disclosed |